Effects of Different Endurance Training Protocols on Physical Performance in Cardiac Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 52
- 试验地点
- 2
- 主要终点
- Physical work capacity (PWC)
研究概览
简要总结
It is the aim of our study to compare the effects of 6 and/or 2 years of either HIT (carried out at correctly assessed 85-95% of maximal heart rate), pyramid, or continuous endurance training, on changes of physical exercise capacity in cardiac patients.
详细描述
The three exercise arms (isocaloric) are composed as follows:
Endurance training: 31 min at 65-75% HRmax, making it a total of 25min; HIT: 4x4min intervals at 85-95% HRmax divided by 3x3min of active recovery at 60-70% HRmax, making it a total of 25 min; Pyramid: One pyramid consists of 8 one-minute blocks. Those are grouped starting with one block of 70-75% HRmax, followed by one block at 75-80% HRmax and another one at 80-85% HRmax. The top of the pyramid are 2 blocks of 85-90% HRmax. Intensity is lowered afterwards with one block of 80-85% HRmax, followed by one block at 75-80% HRmax and last one at 70-75% HRmax. Two more pyramids follow, each divided by 2min of active recovery at 65-70% HRmax, making it a total of 28min.
All protocols are initiated by 5min of warm-up and end with 5min of cool-down, both at 60-70% HRmax.
Primary Outcome: Individual maximum power output in watt (Pmax). Secondary Outcome: Change of power output in watt at lactate tresholds at 2 and 4mmol/l.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •acute coronary syndrome (STEMI - NONSTEMI)
- •aortocoronary bypass surgery
- •percutaneous coronary intervention (PCI)
- •state after stable coronary heart disease
- •state after heart surgeries
- •state after myo-, endo-, or pericarditis
- •state after heart- or lung-transplantation
- •state after heart failure
- •state after pulmonary hypertension
- •state after peripheral venous disease
- •state after electrophysiological surgery
- •state after implantation of an implantable cardioverter or difibrillator
- •Patients at high risk
- •Patients with cardiac dysrhythmias or sudden death
排除标准
- •unstable angina pectoris
- •Heart failure (NYHA IV)
- •acute myo-, endo-, or pericarditis or other infections
- •pulmonary-arterial embolism or phlebothrombosis within 6 months
- •hemodynamic instable dysrhythmias
- •hypertrophic cardiomyopathy
- •medical conditions which prevent patients from complying with the exercise program
结局指标
主要结局
Physical work capacity (PWC)
时间窗: 6 weeks or 36 weeks
PWC will be measured by graded exercise testing on cycle ergometer.
次要结局
- Heart rate(6 weeks or 36 weeks)
- Metabolical and cellular blood parameter(6 weeks or 36 weeks)
- Lactate Thresholds(6 weeks or 36 weeks)
- Blood pressure(6 weeks or 36 weeks)
- Gene expression(6 weeks or 36 weeks)
- Quality of Life(6 weeks or 36 weeks)
- BMI(6 weeks or 36 weeks)
研究者
Prof. Josef Niebauer M.D., Ph.D., MBA
Head of institute
Paracelsus Medical University