High versus Low PEEP in Open Upper Abdominal Surgeries

Ain Shams university hospitals0 个研究点目标入组 60 人开始时间: 2022年7月17日最近更新: 2023年5月29日

适应症

试验速览

暂无简介。

•Age: From 18 years till 55 years.
•-Sex: Male or Female.
•-Expected duration of surgery (from incision to closure) exceeds 2 h.
•-To identify the risk for PPCs, the Assess Respiratory Risk in Surgical Patients in Catalonia (ARISCAT) score is used (Canet el al., 2010). This score predicts individual preoperative risk for PPCs using seven independent predictors, four of which are patient-related and three of which are surgery-related. An ARISCAT risk score =26 is associated with an intermediate to high risk for PPCs.

•-Age: below 18 years or above 55 years.
•-Patient refusal to give written informed consent.
•-Pregnant patients.
•-Patients with persistent hemodynamic instability or intractable shock.
•-Patients with a history of severe chronic obstructive pulmonary disease (COPD); defined as non-invasive ventilation and/or oxygen therapy at home or repeated systemic corticosteroid therapy for acute exacerbations of COPD), severe cardiac disease (defined as New York Heart Association class III or IV, acute coronary syndrome, or persistent ventricular tachyarrhythmia), concurrent acute respiratory distress syndrome (ARDS) expected to require prolonged post-operative mechanical ventilation, severe pulmonary arterial hypertension (defined as systolic pulmonary arterial pressure >40 mmHg).
•-Patients with intracranial injury, or tumour or neuromuscular disease.
•-Morbid obesity: obese patients with BMI =35 kg/m2.
•-Patients who have undergone any kind of previous lung surgery, have been invasively mechanically ventilated for longer than 30 minutes within the last 30 days before surgery, or have received recent immunosuppressive medication (chemotherapy or radiation therapy up to 2 months prior to surgery).
•-Need for one-lung ventilation or planned re-intubation following surgery, or need for intra-operative prone or lateral decubitus position.

发起方