NL-OMON48913
Recruiting
N/A
PROtective ventilation with high versus low PEEP during one-lung ventilation for THORacic surgery - PROTHOR: A randomized controlled trial - The PROTHOR Trial
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Mechanical one lung ventilation and post-operative Pulmonary complications
- Sponsor
- Academisch Medisch Centrum
- Enrollment
- 250
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patient scheduled for open thoracic or video\-assisted thoracoscopic surgery
- •under general anesthesia requiring OLV (no emergency surgery)
- •BMI \< 35 kg/m2
- •age \>\= 18 years
- •expected duration of surgery \> 60 min
- •planned lung separation with double lumen tube (DLT, not for study purpose
- •most of ventilation time during surgery expected to be in OLV
Exclusion Criteria
- •COPD GOLD grades III and IV, lung fibrosis, documented bullae, severe
- •emphysema, pneumothorax
- •uncontrolled asthma
- •Heart failure NYHA Grade 3 and 4, Coronary Heart Disease CCS Grade 3 and 4
- •previous lung surgery
- •documented pulmonary arterial hypertension \>25mmHg MPAP at rest or \> 40 mmHg
- •syst. (estimated by ultrasound)
- •documented or suspected neuromuscular disease (thymoma, myasthenia,
- •myopathies, muscular dystrophies, others)
- •planned mechanical ventilation after surgery
Outcomes
Primary Outcomes
Not specified
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