PRotective Ventilation with Higher versus Lower PEEP during General Anesthesia for Surgery in OBESE Patients - The PROBESE Randomized Controlled Trial - PROBESE

Technische Universität Dresden0 个研究点目标入组 100 人开始时间: 待定最近更新: 2024年4月23日

试验速览

暂无简介。

•Patient scheduled for surgery under general anesthesia
•Intermediate-to-high risk for postoperative pulmonary complications following surgery, according to the ARISCAT risk score (>= 26)
•BMI >= 35 kg/m2
•Expected duration of surgery >= 2 h

•Age < 18 years
•Previous lung surgery (any)
•Persistent hemodynamic instability, intractable shock (considered hemodynamically unsuitable for the study by the patient*s managing physician)
•History of previous severe chronic obstructive pulmonary disease (COPD) (non-invasive ventilation and/or oxygen therapy at home, repeated systemic corticosteroid therapy for acute exacerbations of COPD)
•Recent immunosuppressive medication (patients receiving chemotherapy or radiation therapy up to two months prior to surgery)
•Severe cardiac disease (New York Heart Association class III or IV, acute coronary syndrome or persistent ventricular tachyarrhythmias)
•Invasive mechanical ventilation longer than 30 minutes (e.g., general anesthesia for surgery) within last 30 days
•Pregnancy (excluded by anamneses and/or laboratory analysis)
•Prevalent acute respiratory distress syndrome expected to require prolonged postoperative mechanical ventilation
•Severe pulmonary arterial hypertension, defined as systolic pulmonary artery pressure > 40 mmHg
•Intracranial injury or tumor
•Neuromuscular disease (any)
•Need for intraoperative prone or lateral decubitus position
•Need for one-lung ventilation
•Cardiac surgery
•Neurosurgery
•Planned reintubation following surgery
•Enrolled in other interventional study or refusal of informed consent

发起方