NL-OMON44595
Completed
Not Applicable
PRotective Ventilation with Higher versus Lower PEEP during General Anesthesia for Surgery in OBESE Patients - The PROBESE Randomized Controlled Trial - PROBESE
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Technische Universität Dresden
- Enrollment
- 100
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patient scheduled for surgery under general anesthesia
- •Intermediate\-to\-high risk for postoperative pulmonary complications following surgery, according to the ARISCAT risk score (\>\= 26\)
- •BMI \>\= 35 kg/m2
- •Expected duration of surgery \>\= 2 h
Exclusion Criteria
- •Age \< 18 years
- •Previous lung surgery (any)
- •Persistent hemodynamic instability, intractable shock (considered hemodynamically unsuitable for the study by the patient\*s managing physician)
- •History of previous severe chronic obstructive pulmonary disease (COPD) (non\-invasive ventilation and/or oxygen therapy at home, repeated systemic corticosteroid therapy for acute exacerbations of COPD)
- •Recent immunosuppressive medication (patients receiving chemotherapy or radiation therapy up to two months prior to surgery)
- •Severe cardiac disease (New York Heart Association class III or IV, acute coronary syndrome or persistent ventricular tachyarrhythmias)
- •Invasive mechanical ventilation longer than 30 minutes (e.g., general anesthesia for surgery) within last 30 days
- •Pregnancy (excluded by anamneses and/or laboratory analysis)
- •Prevalent acute respiratory distress syndrome expected to require prolonged postoperative mechanical ventilation
- •Severe pulmonary arterial hypertension, defined as systolic pulmonary artery pressure \> 40 mmHg
Outcomes
Primary Outcomes
Not specified
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