Plasma Brain Natriuretic Peptide Levels in Pregnancy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 50
- 试验地点
- 1
研究概览
简要总结
To evaluate the maternal blood concentrations of brain natriuretic peptide (BNP) during the second and third trimesters of a normal pregnancy. We will attempt to define a normal range for pregnancy and any outliers that may serve as markers for abnormal cardiovascular physiology.
详细描述
The brain natriuretic peptide (BNP) is a useful marker for volume overload, increased filling pressures and stretching of the myocardium. The current literature contains limited and unreliable information regarding normal BNP values in pregnancy. After baseline echocardiogram to detect individuals with asymptomatic structural defects, the participants will submit to 3 blood draws during the second and third trimester and at delivery to determine normal pregnancy values.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •women age 18 to 40
- •second trimester of pregnancy
排除标准
- •known cardiac or valvular disease,
- •atrial fibrillation or other arrhythmia,
- •pulmonary hypertension,
- •chronic hypertension,
- •hypertensive disorders of pregnancy,
- •morbid obesity (BMI > 40 kg/meter squared)
- •history of sleep apnea
- •multiple gestation
- •known renal dysfunction
- •medications known to affect cardiac function
- •current or past abnormal echocardiogram