NCT00734266已完成不适用
Changes in Leukotrienes During Cardiac Surgery in Patients With Chronic Obstructive Pulmonary Disease
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 主要终点
- urine cysteinyl leukotriene
研究概览
简要总结
The hypotheses of this study are that:
- Production and release of inflammatory substances called leukotrienes are increased during heart surgery with use of a heart-lung machine in humans;
- The increase in these leukotrienes levels after heart surgery is higher in patients with bronchitis and/or emphysema than in patients without previous history of lung disease;
- Levels of leukotrienes are directly correlated with worsening of lung function during and after heart surgery.
详细描述
In this project, we will test the hypothesis that cys-leukotrienes are released and correlated with the impairment of the lung function after cardiac surgery in patients with COPD. If such hypothesis is substantiated in the study, it would allow us to propose the use of leukotriene inhibitors in the peri-operative period to improve pulmonary function and to decrease complications after cardiac surgery in COPD patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients schedules to undergo cardiac surgery with use of CPB.
排除标准
- •inability to provide consent;
- •previous diagnosis of asthma;
- •acute pre-operative respiratory failure;
- •emergency surgery.
结局指标
主要结局
urine cysteinyl leukotriene
时间窗: intra-operative
次要结局
未报告次要终点
研究者
Marcos Vidal Melo
Associate Professor of Anesthesia
Massachusetts General Hospital
相似试验
已完成
不适用
Perioperative myocardial ischemia and cytokine response in patients undergoing high-risk surgery; the influence of fluvastatin.statinperioperativevascular surgeryinflammationNL-OMON27929Erasmus MC, Rotterdam, the Netherlands.500
已完成
不适用
Inflammatory Cytokine Variations in Traumatic Injury ResponsesTraumatic Complication of InjuryNCT00593892University of Alabama at Birmingham90
已完成
不适用
Perioperative Troponin I and NT Pro-BNP in Lung ResectionCardiac IschemiaThoracic CancerComplication,PostoperativeNCT04749212Hospital Universitari Vall d'Hebron Research Institute475
已完成
4 期
Colchicine in Coronary Artery Bypass Graft (CABG)Elective Coronary Artery Bypass Graft SurgeryNCT02122484G.Gennimatas General Hospital60
进行中（未招募）
不适用
The Effect of Perioperative Lidocaine Infusion on Neutrophil Extracellular TrappingUrologic CancerNCT04840511The Catholic University of Korea60