Sleep, Energy Metabolism and Diabetes Risk.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Total body insulin sensitivity
研究概览
简要总结
The use of sugar and starch-like foods for energy (carbohydrate metabolism) changes when people sleep. However, it is still not known if differences in the amount of nighttime sleep have an effect on the carbohydrate metabolism of people who have a relative with type 2 diabetes (parent, sibling, or grandparent). This study is being done to test the hypothesis that individual differences in habitual sleep duration may be related to differences in the carbohydrate metabolism of people who have a history of type 2 diabetes in their family.
详细描述
On two consecutive inpatient days, the participants in this study will undergo two different tests. The first test will determine how much insulin can their body produce in response to an intravenous glucose infusion over a period of several hours. The second test will determine how effective is the action of the sugar-processing hormone, insulin, in their body when it is infused intravenously together with glucose over a period of several hours.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 21 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •regular sleep habits
- •BMI 20 to 27 kg/m2
- •at least one parent, sibling or grandparent with type 2 diabetes
- •no regular exercise habits
排除标准
- •active smoker
- •night or shift work
- •have highly variable sleep habits
- •have a hormonal disorder
- •have a sleep disorder
- •have an active medical problem
- •women only: use of birth control pills
- •women only: irregular menstrual periods or pregnancy
- •use of medications/compounds that can disrupt sleep
结局指标
主要结局
Total body insulin sensitivity
时间窗: at the end of a 4-hour hyperinsulinemic clamp
次要结局
- First and second phase insulin secretion(during a 3-hour hyperglycemic clamp)
- Endogenous glucose production(before and during a 4-hour hyperinsulinemic clamp)
- Glycerol turnover and free fatty acid concentration(before and during a 4-hour hyperinsulinemic clamp)