NL-OMON49617招募中不适用
Reduced Microvascular Blood Volume as a Driver of Coronary Microvascular Disease in Patients with Non Obstructive Coronary Artery Disease - MICORDIS study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 61
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Patient group:
- •- Age > 40 years
- •- Signed informed consent
- •- Stable and chronic symptoms suggesting ischemic heart disease
- •- NOCAD on coronary angiography: coronary artery stenosis <= 50% and/or FFR >
- •- Prior transthoracic echocardiographic assessment
- •Control group:
- •- Age > 40 years
- •- Signed informed consent36 bgc
排除标准
- •- Age > 80 years
- •- Obstructive coronary artery disease, defined as more than 50% obstruction of
- •any coronary artery
- •- FFR < 0.80
- •- Use of medication for the control group
- •- Persons working at the department of Cardiology from the VU university
- •medical centre
- •- Persons involved in the study
- •- Family (partner, parents, child, brother or sister or statutory person) from
- •persons working at the department of Cardiology from the VU university medical
- •centre, or who are involved in the study
- •- Pregnancy
- •- History of coronary revascularization (e.g. percutaneous coronary
- •intervention or coronary artery bypass grafting)
- •- History of coronary artery disease, or acute coronary syndrome (e.g.
- •myocardial infarction and unstable angina pectoris)
- •- History of stroke
- •- History of cardiac arrhythmia*s
- •- History of heart valve disease
- •- Left ventricular dysfunction
- •- Congenital heart disease
- •- Insulin-dependent diabetes mellitus
- •- Extensive comorbidities (i.e. cancer, other chronic diseases)
- •- Impaired renal function, defined as creatinine > 100 and eGFR < 60.
- •- Symptomatic asthma or chronic obstructive pulmonary disease
- •- Known allergic reaction to contrast agent
- •- Insufficient echocardiographic imaging quality
- •- Contra-indications for CMR (e.g. severe claustrophobia, metal implants,
- •severe renal failure, severe asthma and known hypersensitivity for gadolinium)
- •- Contra-indications for microbubble usage (e.g. right-to-left shunt, severe
- •pulmonary hypertension, uncontrolled hypertension and adult respiratory
- •distress syndrome)
- •- Contra-indications for adenosine usage (e.g. hypersensitivity to active
- •substances, second or third degree atrio-ventricular block, sick sinus
- •syndrome, long QT syndrome, severe hypertension, concomitant use of
- •dipyridamole)
- •- Contra-indications for dobutamine usage (e.g. hypersensitivity to dobutamine,
- •severe heart failure, acute pericarditis, myocarditis or endocarditis, aortic
- •dissection or aneurysm, inadequately controlled arterial hypertension or
- •hypotension, hypovolemia)
研究者
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