Monitoring Neural Tissues Properties by Modulated Imaging (MI)
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 2
- 主要终点
- Brain Tissue Property
研究概览
简要总结
We have developed a safe, non-contact, intra-operative guidance system to optimize tumor resection in neurosurgery. The Modulated Imaging is non-contact optical imaging technology developed at the Beckman Laser Institute, UCI.
Compared to other imaging approaches, MI has the unique capability of performing both diffuse optical tomography and rapid, wide-field quantitative mapping of tissue optical properties within a single measurement platform.
Preliminary in vivo studies have shown that brain tumors, infiltrating tumor margins and normal brain may have intrinsically different optical properties.
详细描述
While compatible with time-modulation methods, MI alternatively uses spatially-modulated illumination for imaging of tissue constituents.
The Modulated Imaging system consists of
- a light projection system that illuminates the tissue with spatial sinusoid patterns.
- a CCD camera which collects the diffusely reflected light in a non-contact geometry. The wavelength of illumination can be selected by bandpass filtering of a broadband source,or by use of a monochromatic source.
Lastly, tissue fluorescence measurements can be performed by placing a combination of source-blocking and bandpass emission filters in front of the camera.
The diffusely reflected amplitude of the modulated wave carries both optical property (absorption, fluorescence, scattering) and depth information. Specifically, the sampling depth of the spatially-modulated wave is a function of the frequency of illumination and the tissue optical properties.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 1 Minute 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All nervous system tumor patients who undergo a preoperative MRI,and undergoing central nervous system operative procedures for non tumor.
排除标准
- •All emergency neurosurgical procedures.
结局指标
主要结局
Brain Tissue Property
时间窗: 12 weeks
次要结局
未报告次要终点
研究者
Beckman Laser Institute and Medical Center
Mark Linskey, MD.,Department of Neurosurgery
University of California, Irvine