INcrétines et REModelage OSseux
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 104
- 试验地点
- 1
- 主要终点
- incretins concentrations before and after a meal in healthy subjects
研究概览
简要总结
The role of incretins (GIP and GLP-1) on cells and bone tissue has been shown in cellular and animal studies. In humans, the role of these hormones is mainly studied in the pathophysiology of diabetes, their effect on bone is unknown. The serum incretin concentration is low and increases rapidly after a meal. This increase is brief, incretins being rapidly degraded by dipeptidylpeptidase 4 (DPP-4). The dosage of these hormones is complex and the basal "normal" serum concentrations and after feeding in healthy subjects are unknown. Before any study on the effect of incretins on bone remodeling in humans, it is necessary to establish physiological concentrations of incretins in healthy subjects.
The aim of this study is to estimate physiological concentrations of incretins in healthy subject.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 30 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy women and men
排除标准
- •known osteoporosis
- •osteoporotic fracture
- •alcohol : > 2 glasses/day
- •type 1 and type 2 diabetes
- •BMI < 19kg/m² or > 30kg/m²
- •heart failure, kidney failure
- •bariatric surgery
- •cirrhosis
- •use in the past year : bisphosphonate, denosumab, raloxifene, teriparatide, oral or IV glucocorticoid during 3 months or more
结局指标
主要结局
incretins concentrations before and after a meal in healthy subjects
时间窗: 2 years
次要结局
未报告次要终点