Effect of Intra-venous Oxytocin Injection After Fetal Expulsion in Management of Third-stage of Labor After Second Trimester Medical Pregnancy Termination
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 27
- 试验地点
- 2
- 主要终点
- Incidence of placental retention
研究概览
简要总结
Prospective randomized trail which compare 2 regimens for third-stage management after second trimester medical pregnancy termination : 10UI intra venous oxytocin or no additional medication after fetal expulsion. Primary outcome was the incidence of placental retention.
详细描述
Complication of third stage of labor in second trimester medical pregnancy termination is not well studied. Accord to publications, the placental retention rate is 30 to 40% in these situations. Placental retention may be associated with increased blood loss, increased requirement for blood transfusion anesthetic and operative complications, and infectious morbidity. The high incidence of retained placenta is an area of clinical concern. Publications reveal a wide variation in practices but there are only few studies about third stage of labor in second trimester medical pregnancy termination. The study is a prospective randomized trial. Two third stage management strategies are compared: 10 units of intra venous oxytocin (group 1) and no additional medication (group 2) after fetal expulsion. It concerns pregnancies between 14 and 28 weeks gestation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •18 years old and older
- •medical pregnancy termination between 14 and 28 weeks gestation
- •informed consent obtained
排除标准
- •less than 18 years old
- •refusal to consent
- •in utero fetal death
研究组 & 干预措施
Oxytocin administration after fetal expulsion
Administration of 10 units of intra venous oxytocin after fetal expulsion
干预措施: Administration of 10 units of intra venous oxytocin after fetal expulsion (Drug)
结局指标
主要结局
Incidence of placental retention
时间窗: Up to 30 minutes after fetal expulsion
次要结局
- Incidence of partial placental retention(Up to 1 hour after fetal expulsion)
- Incidence of digital exploration(Up to 1 hour after fetal expulsion)
- Incidence of blunt curettage(Up to 1 hour after fetal expulsion)
- Incidence of post-partum hemorrhage(Up to 1 hour after fetal expulsion)
- Blood loss(Up to 1 hour after fetal expulsion)