Effects of Cognitive and/or Physical Exercises Blended by Computer Games in Elderly: The LLM Project Neuroscientific Investigations in Thessaloniki, Greece by the LLM Team at the Aristotle University of Thessaloniki
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 581
- 主要终点
- overall cognition
研究概览
简要总结
The study involved Information and Communication Technologies (ICT) and more specifically computer exercises blended with game activities. It was hypothesized that ICT facilitated, game blended cognitive and/or physical exercise improves global cognition when compared to control groups; moreover, these improvements may be manifested by brain activity changes; we explored the impact of potential moderators on combined exercise-induced cognitive benefits, as well as, individual/separate training schemes.
详细描述
The study was conducted in the Thessaloniki (Greece), in various centers. It was part of the Long Lasting Memories (LLM) project (www.longlastingmemories.eu), which was funded by the European Commission (Information and Communication Technologies Policy Support Program (ICT-PSP) for a three year period (2009-2012). It used a pre-post-test design with the between-participant factor group [intervention(s) vs. passive and/or active control]. Post-test was conducted within 2 weeks after completion of the exercise period. Interventions were carried out in Thessaloniki (Greece) within day care centers, hospitals, senior care centers, a memory outpatient center, local parishes, and at participants' homes.
Centers had to provide 8 exercise weeks, with a frequency of at least 2 physical and 3 cognitive exercise sessions per week, resulting in at least 16 physical and 24 cognitive exercise sessions in total.
A similar trial was registered with Clinical Trial Registration: ClinicalTrials.gov Identifier: NCT02267499
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 55 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •no severe cognitive impairment [MMSE ≥ 18]
- •fluent language skills
- •agreement of a medical doctor
- •time commitment to the test and exercise protocol.
排除标准
- •concurrent participation in another study
- •severe physical or psychological disorders which precluded participation in the intervention (i.e., inability to follow instructions)
- •unrecovered neurological disorders such as stroke, traumatic brain injury, unstable medication within the past three months
- •severe and uncorrectable vision problems, or hearing aid for less than three months.
结局指标
主要结局
overall cognition
时间窗: 2 Monhths
Greek versions of the California Verbal Learning Test \[CVLT\], the Digit Span Test and the Trail Making Test \[TMT\] were used to assess cognitive outcomes
次要结局
- Depressive symptoms(2 months / 6+2 months / 12+2 months)
- Instrumental Activities of daily living(2 months / 6+2 months / 12+2 months)
- Brain function(2 months)
- physical fitness(2 months / 6+2 months / 12+2 months)
- Episodic memory(2 months / 6+2 months / 12+2 months)
- working memory(2 months / 6+2 months / 12+2 months)
- executive function(2 months / 6+2 months / 12+2 months)
- Quality of Life(2 months / 6+2 months / 12+2 months)
研究者
Panos Bamidis
Project Co-ordinator
Aristotle University Of Thessaloniki