Effect of Short-term Motor Training on Accuracy and Precision of Knee Movement in Human With and Without Knee Pain
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- knee movement assessment
研究概览
简要总结
The objects of this research are to investigate the ability of the motor learning and test the possible differences between younger and older healthy human, and between non-pain and acute experimental pain and chronic clinical pain conditions.
详细描述
The project consists of four experimental studies. In the first experiment, younger and older healthy human subjects are involved in a short-term neuromuscular training on the accuracy and precision of knee movement to investigate the possible age effect of the motor learning. The second experiment focuses on the experimental pain on the learning effect of the younger subjects. The third experiment will investigate a group of knee osteoarthritis patients to show the influence of chronic pain on the motor training compared with age-, gender-matched pain free subjects. 3D camera tracking system will be used to record the knee movements at the baseline and after 6-day motor task training. The variability in amplitude of the values of knee movements was transformed to percentage in relation to the target position (accuracy) or to the mean position (precision). The results of the study will contribute to both basic and clinical understanding of the mechanisms related to knee movement control and influences of varies painful conditions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •• Aged 18-30 or 50-65 years
- •Free from ongoing or chronic pain
- •Right dominant leg
- •Speak and understand English
- •Aged 50-65 years.
- •Diagnosed with knee OA (according to American College of Rheumatology classification) with pain in left or both knees for more than six months
- •Have ongoing pain rated above 2 on a 0-10 Visual Analogues Scale (VAS) in the previous week.
- •Right dominant leg
- •Speak and understand English
- •Aged 50-65 years
- •Diagnosed with knee OA
- •Have had total knee arthroplasty on left or both knees
- •Right dominant leg
- •Speak and understand English
排除标准
- •• Pregnancy or intent to become pregnant, breast feeding
- •Regular use of analgesics, including simple analgesia and NSAIDs
- •Frequent recreational drug or alcohol use
- •History of knee joint pathology or injury
- •Previous neurologic, musculoskeletal or mental illnesses
- •Practicing sport activities on a regular basis
- •Lack of ability to cooperate
- •Regular use of analgesics, including analgesia and NSAIDs for the last 24 hours
- •Frequent recreational drug or alcohol use
- •Previous neurologic, musculoskeletal or mental illnesses
- •Practicing sports activities on a regular basis
- •Lack of ability to cooperate
- •Regular use of analgesics, including analgesia and NSAIDs for the last 24 hours
- •Frequent recreational drug or alcohol use
- •Other disorders or injuries in the knee joints
- •Previous neurologic, musculoskeletal or mental illnesses
- •Practicing sports activities on a regular basis
- •Lack of ability to cooperate
研究组 & 干预措施
Hypertonic saline
A bolus injection (0.25 ml) of hypertonic saline (5%) is injected into the left infrapatellar fat pad.
干预措施: Hypertonic saline (Drug)
Hypertonic saline
A bolus injection (0.25 ml) of hypertonic saline (5%) is injected into the left infrapatellar fat pad.
干预措施: Motor training (Other)
Isotonic saline
A bolus injection (0.25 ml) of isotonic saline (0.9 %) is injected into the left infrapatellar fat pad.
干预措施: isotonic saline (Drug)
Isotonic saline
A bolus injection (0.25 ml) of isotonic saline (0.9 %) is injected into the left infrapatellar fat pad.
干预措施: Motor training (Other)
Motor training
All the subjects recruited need to have a short-term motor task training at home. 30 times a session, totally 2 sessions a day for 6 days
干预措施: Motor training (Other)
结局指标
主要结局
knee movement assessment
时间窗: Change from baseline, up to 7 days after the first session
There are two sessions in total, seperated by a 6 days motor training. Using 3D camera to calculate the accuracy and precision of knee movements at 30, 45, 60 degree respectively both with and without visual feedback (baseline), before and after motor training, also before and after injection.
次要结局
- Assessment of pain(Only on day 7 (second session), up to 24 hours)
研究者
Kelun Wang
Associate professor
Aalborg University