Effects of Soluble Fiber Consumption on Body Weight, Glycemia, and Insulinemia in Adults With Overweight and Obesity: a Systematic Review and Meta-analysis of Randomized Controlled Trials.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 609
- 试验地点
- 1
- 主要终点
- Body weight (kg)
研究概览
简要总结
Dietary fiber intake is protective against overweight and obesity; however, a significant fiber gap exists between consumption and recommended intake values. Soluble fiber beneficially impacts metabolism, and supplementation may be a feasible approach to improve body composition and glycemia in overweight and obese individuals. The investigators will evaluate results of randomized controlled trials (RCTs) of soluble fiber supplementation among overweight and obese adults for outcomes related to weight management (e.g. body mass index [BMI], body weight, body fat percentage, waist circumference) and glucose and insulin homeostasis (e.g. fasting glucose, homeostasis model assessment of insulin resistance [HOMA-IR], fasting insulin) through systematic review and meta-analysis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Peer-reviewed randomized controlled trials (RCTs) will be included in the systematic review and meta-analysis if they involve participants who are:
- •Overweight or obese (BMI ≥ 25.0 kg/m2 for U.S. populations and ≥ 23.0 kg/m2 for Asian populations and/or waist circumference ≥ 40 inches (94 cm) in men or ≥ 35 inches (80 cm) in women and/or waist-to-hip ratio ≥ 0.90 in men or ≥ 0.85 in women).
- •Weight stable and not actively trying to lose weight at screening.
- •Without physician-diagnosed chronic conditions at screening (e.g., dyslipidemia, hypertension, type 2 diabetes, and cardiovascular disease).
- •Included studies will be soluble fiber supplementation interventions that are controlled feeding studies or conducted among free-living subjects that provide data for outcomes of interest.
排除标准
- •Studies will be excluded from the systematic review and meta-analysis if they meet any of the following criteria:
- •Studies conducted in animals.
- •Mechanistic research.
- •Human trials involving pregnant women, breastfeeding women, or children.
- •Conference proceedings.
- •Articles not published in English.
- •Studies less than 1 week in duration.
- •Studies that pool outcome measure data for healthy weight and overweight and obese individuals.
- •Studies involving whole food treatments or high fiber profile diets.
- •Weight loss interventions involving other tactics, such as counseling or energy restriction.
结局指标
主要结局
Body weight (kg)
时间窗: ≥ 1 week
Body fat (% fat mass)
时间窗: ≥ 1 week
Fasting glucose (mmol/l)
时间窗: ≥ 1 week
Body mass index (kg/m2)
时间窗: ≥ 1 week
Waist circumference (cm)
时间窗: ≥ 1 week
Fasting insulin (pmol/l)
时间窗: ≥ 1 week
Homeostasis Model Assessment of Insulin Resistance (HOMA-IR)
时间窗: ≥ 1 week
次要结局
未报告次要终点