The efficacy of three weeks’ daily supplementation with two-combined probiotic strains on infant colic

Angel Children’s Hospital0 个研究点目标入组 112 人开始时间: 2019年12月10日最近更新: 2021年10月11日

适应症

试验速览

2021 Results article in https://pubmed.ncbi.nlm.nih.gov/34568236/ (added 28/09/2021)

•1. Crying or fussing episodes lasting more than 3 hours per day and occurring at least 3 days per week within 7 days prior to enrollment (ROME IV criteria)
•2. Less than 3 months (12 weeks) of age
•3. Equal to or greater than 37 weeks of gestation at birth
•4. Vaginal delivery
•5. Birth weight of more than 2500g
•6. Provided voluntary written informed consent from parents of the infant

•1. Average weight gain < 100 grams/week from birth to the last recorded weight
•2. Major medical problems (e.g. immunocompromised disease, major developmental or genetic abnormality)
•3. Gastrointestinal disorder
•4. Taking antibiotics four weeks prior to enrollment
•5. Using the same probiotic strains in this study two weeks prior to enrollment
•6. Taking antibiotics during the intervention

发起方

Angel Children’s Hospital