NCT02230839进行中（未招募）不适用
Muscle Insulin Resistance In Aging
AdventHealth Translational Research Institute2 个研究点 分布在 1 个国家目标入组 200 人开始时间: 2014年6月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 200
- 试验地点
- 2
- 主要终点
- Measure of intramyocellular lipids
研究概览
简要总结
The purpose of this study is to provide information regarding potential factors underlying metabolic dysfunction, insulin resistance, and loss of muscle mass in aging muscle.
详细描述
Study Objectives:
- To determine the effects of diet-induced weight loss with and without the addition of exercise on mitochondrial biogenesis and energetic capacity, cellular redox state and insulin resistance.
- To determine the effects of diet-induced weight loss with and without the addition of exercise on intramyocellular lipid profiles.
- To determine the effects of diet-induced weight loss with and without exercise on skeletal muscle proteins mediating a program of autophagy and either loss or maintenance of muscle mass.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 65 Years 至 80 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •65-80 years of age
- •Stable weight (No Gain/Loss of >10 lbs in 6 months)
- •Sedentary (≤ 1 continuous exercise/week)
- •Non-smoker
- •BMI ≥ 30 kg/m2
- •Resting Blood Pressure ≤ 150 millimeters of mercury systolic and ≤ 95 millimeters of mercury diastolic
- •Note from Primary care physician/Cardiologist for exercise clearance if positive stress test symptoms were observed from exercise test
- •Must be willing to washout for 14 days from all diabetes medication and independent in self blood glucose monitoring during the washout periods (those with diabetes only)
排除标准
- •Clinically significant cardiovascular disease including history of myocardial infarction, within the past year
- •Peripheral Vascular Disease
- •Hepatic, renal, muscular/neuromuscular, or active hematologic/oncologic disease
- •Clinically diminished pulse
- •Presence of bruits in lower extremities
- •Previous history of pulmonary emboli
- •Peripheral Neuropathy
结局指标
主要结局
Measure of intramyocellular lipids
时间窗: Visit 3 ~22 hours
A percutaneous muscle biopsy of the vastus lateralis will be obtained, and the intramyocellular lipids will be measured by high-performance liquid chromatography-tandem mass spectrometry.
次要结局
- Measure of insulin sensitivity(Visit 3 ~22 hours)
研究者
研究点 (2)
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