Determination of Dietary Protein Requirements in Healthy Women During Stages of Lactation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 13
- 试验地点
- 2
- 主要终点
- 13C Phenylalanine Oxidation
研究概览
简要总结
It is well established that a breast-feeding women need more protein in their diet compared to non-lactating women, but how much additional protein is needed remains unclear. There is reason to believe that the current Dietary Reference Intake (DRI) recommendations for breast-feeding women are too low. To gain better understanding, we plan to study healthy breast-feeding women 20 - 45 yrs, between 3 - 5 months lactation and 6 - 8 months lactation. We will use the indicator amino acid oxidation technique (IAAO), which is a modern, quick and safe research method.
详细描述
Purpose:
To determine the dietary protein intake requirement in healthy lactating women during the exclusive breast-fed period (3 - 5 months lactation) and during weaning (6 - 8 months lactation).
Hypothesis:
Recent stable isotope-based research using the IAAO technique indicate that current protein intake recommendations are underestimated in adults by ~40 %, in school aged children ~75 % and pregnant women during early and late gestation by ~39 % and ~73 %, respectively.
Therefore we hypothesize that that protein requirements will be increased during both phases of lactation above that of the current recommendations
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Healthy lactating women
- •With a healthy baby
- •Exclusively breast feeding (3 - 5 months) and are partially breast-feeding women (6 - 8 months) - not supplementing with infant formula
排除标准
- •Women below 20 yrs or above 45 yrs of age
- •Women who are breast-feeding more than one child
- •Women who are not exclusively breast feeding (3 - 5 months) and women who are supplementing with infant formula or have not transitioned to solid foods by 6 - 8 months.
- •Women not in good health and have a metabolic, neurological, genetic, or immune disorder.
- •Women who are claustrophobic (we will place a clear hood, which can easily be removed, over the participants head for approximately 20 min to measure energy expenditure).
- •Women who are substance dependent (i.e. alcohol, cigarette, illicit drugs)
- •Women who are allergic to eggs and egg protein
- •Women who do not have a healthy baby
结局指标
主要结局
13C Phenylalanine Oxidation
时间窗: 8 hours
Urine, breath and a single blood sample will be collected during the study to measure the rate of oxidation of 13C phenylalanine.
次要结局
未报告次要终点
研究者
Rajavel Elango, PhD
Principal investigator
University of British Columbia