NCT01919957Unknown不适用
Etude de la mémoire Avant et après Chirurgie d'Une épilepsie Partielle pharmacorésistante : Bases Neurobiologiques, Applications Cliniques
Institut National de la Santé Et de la Recherche Médicale, France2 个研究点 分布在 1 个国家目标入组 120 人开始时间: 2013年10月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 120
- 试验地点
- 2
- 主要终点
- Measure of successfull encoding
研究概览
简要总结
This study has two purposes: firstly, a better understanding of the neurobiological processes underlying episodic memory and, secondly, the development of useful clinical applications for epileptic patients, in particular the prediction of postoperative memory deficits and the development of cognitive remediation therapies.
Memory performances during a fMRI experiment will be assessed in controls and epileptic patients before and after the surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with drug-resistant epilepsy
- •Age of 18 years or more
- •Follow-up in the epilepsy unit at Pitié-Salpêtrière Hospital
- •Before or after the presurgical evaluation unit including a video-EEG monitoring, a structural brain imaging and a full neuropsychological assessment
- •Covered by a social security system
- •Signing of consent form
排除标准
- •Persons under guardianship, curatorship or any other administrative or judicial deprivation of rights and freedom
- •Refusal to consent form
- •Contraindications to MRI
- •Pregnancy
- •Refusal to be informed in the case of detection of an abnormality during the experiment
结局指标
主要结局
Measure of successfull encoding
时间窗: 8 years
Our goal is to define correlation between the measure of successfull object encoding trials (especially for binding) and the beta value activation in fMRI
次要结局
未报告次要终点
研究者
研究点 (2)
Loading locations...
相似试验
Unknown
不适用
Neuropsychological and Neuroimaging Evaluation of the Cognitive Impairment in Aortic Valve Replacement (ARTiCO)Aortic Valve StenosisTranscatheter Aortic Valve ReplacementSurgical TreatmentCognitive ImpairmentStrokeNCT05235529Germans Trias i Pujol Hospital72
招募中
不适用
Postoperative Clinical and Neurophysiological Assessment of Patients After Open Heart SurgeryPostoperativeClinicalNeurophysiological AssessmentOpen Heart SurgeryNCT06707454Ain Shams University80
Unknown
不适用
Neurobiological Changes When Treating Depression With Electroconvulsive Therapy - a Longitudinal Observational StudyDepressionNCT01869868Linkoeping University50
招募中
不适用
Cognitive Impact Associated With Surgery For Gastric Or Esophageal CancerGastroesophageal Cancer (GC)Postoperative Delirium (POD)Quality of Life (QOL)FrailtyMalnutritionSarcopeniaChemobrainChemotherapyDepressionNCT06687291Karolinska Institutet130
已完成
不适用
Postoperative Neurocognitive DisordersObstructive Sleep ApneaNeurocognitive DisordersNCT04244162Massachusetts General Hospital32