NCT02100293已完成不适用
Effects of Magnesium Sulfate on Onset and Duration of Low Dose Rocuronium
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 84
- 试验地点
- 1
- 主要终点
- onset time of rocuronium
研究概览
简要总结
This study aims to evaluate effects of magnesium sulfate on onset and duration of low dose rocuronium, intubation condition and surgical condition.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18-75 yr American Society of Anesthesiologists physical status 1 or 2, BMI of 20-24.9 kg/m2 scheduled for elective laryngeal microsurgery
排除标准
- •severe respiratory or cardiac disease hepatic or renal function impairment neuromuscular disease on medications affecting neuromuscular function with known allergy to the drugs
研究组 & 干预措施
standard dose rocuronium group
Active Comparator
pretreatment of saline 100ml and rocuronium 0.6 mg/kg
干预措施: saline (Drug)
low dose rocuronium group
Active Comparator
pretreatment of saline 100ml and rocuronium 0.45 mg/kg
干预措施: saline (Drug)
low dose rocuronium plus magnesium group
Active Comparator
pretreatment of magnesium sulfate 30 mg/kg and rocuronium 0.45 mg/kg
干预措施: magnesium sulfate 30 mg/kg (Drug)
结局指标
主要结局
onset time of rocuronium
时间窗: from injection of rocuronium to T1 suppression more than 95% up to 10 minutes
from injection of rocuronium to T1 suppression more than 95% up to 10 minutes
次要结局
- maximal suppression time and duration of rocuronium(time from the injection of rocuronium to T1 maximal suppression time and reversal of T1 25% up to 1 hours)
研究者
研究点 (1)
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