CORTIFRENCH - Benefit of a flash dose of corticosteroids in digestive surgical oncology: a randomized, double blind, placebo-controlled trial - CORTIFRENCH

Centre Hospitalier Universitaire De Dijon0 个研究点目标入组 1,200 人开始时间: 2024年6月24日最近更新: 2024年7月22日

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•Age > or = 18 years, Elective surgery for any digestive cancer (except purely hepatic surgery), Patients operated in a curative intent, Patients who had given their written informed consent, Patients affiliated to a National health insurance scheme

•Emergency surgery, Persons subject to a court order, Impossibility to adhere to the medical follow-up of the trial for geographical, social or psychological reasons, Secondary exclusion criteria : live vaccine or live attenuated vaccine administered within 1 month preceding surgery, Secondary exclusion criteria : cancelled surgery without deferral, Pregnant or breastfeeding women, Patients with an ongoing oral treatment by steroids, Palliative surgery, Exclusive liver surgery, concomitant hyperthermic intraperitoneal chemotherapy, Patient with at least one contra-indication to methylprednisolone treatment : * active infection * progressive/symptomatic viral infection(particularly hepatitis, herpes, chickenpox, herpes zoster) * uncontrolled psychotic state * hypersensitivity to methylprednisolone or to one of its excipients, ASA grade >3, Persons subject to a measure of legal protection (guardianship, tutorship)

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