A comparative study between 0.75% hyperbaric ropivacaine and 0.5% hyperbaric levobupivacaine for spinal anaesthesia in lower limb orthopaedic surgeries

TITLE OF THESIS

A COMPARATIVE STUDY BETWEEN 0.75% HYPERBARIC ROPIVACAINE AND 0.5% HYPERBARIC LEVOBUPIVACAINE FOR SPINAL ANAESTHESIA IN LOWER LIMB ORTHOPAEDIC SURGERIES.

INTRODUCTION

New long-acting local anaesthetics, levobupivacaine and ropivacaine, both being pure left-isomers of bupivacaine and due to their three-dimensional structure seem to have lesser toxic effects on the central nervous system and the cardiovascular system. Through my study I intend to clinically compare the efficacy of 0.75% hyperbaric ropivacaine and 0.5% hyperbaric levobupivacaine in spinal anaesthesia.

AIMS AND OBJECTIVES

AIM:

To compare the duration of analgesia between 0.5% hyperbaric ropivacaine and 0.5% hyperbaric levobupivacaine for spinal anaesthesia in patients undergoing lower limb orthopaedic surgeries.

OBJECTIVES:

PRIMARY:

A)      To compare the onset of sensory block in two drugs.

B)      To compare the onset of motor block in two drugs.

SECONDARY:

A)      To compare the effect of the two drugs on hemodynamic parameters.

B)      To evaluate any adverse effects.

MATERIALS AND METHODS AND DATA COLLECTION PROCEDURE

A total of 70 patients will be randomly divided into two groups of 35 patients each. Group A will receive 15 mg 0.5% (3 ml) hyperbaric levobupivacaine for spinal anaesthesia. Group B will receive 22.5 mg 0.75% (3 ml) hyperbaric ropivacaine for spinal anaesthesia.

Onset and time taken for regression of sensory and motor block will be recorded after every 3 minutes for the first 15 min after injection then every five minutes for the next 25 min and at 60, 90, 120, 180, 240, 300, 360, 420, 480 minutes. Duration of analgesia will be assessed using Numerical Rating Scale Score at 2, 4, 6 and 12 hours in the post-operative period. Heart rate and Blood Pressure will be monitored at 5 minutes interval for first 15 minutes followed by 15 minutes interval till 90 minutes and then at every 30 minutes interval.

|RESULTS AND ANALYSIS

The result will be statistically analyzed using appropriate statistical formula and will be presented using textual, tabular and graphical form.

|CONCLUSION

After detailed discussion of the results and observation of the study, conclusion will be drawn in relation to above mentioned objectives of study.

REFERENCES

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