Best Revascularisation Approach for Posterior Circulation Strokes With Isolated Vertebral : the BRAVO Retrospective Analysis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 682
- 试验地点
- 1
- 主要终点
- 3-month modified Rankin scale
研究概览
简要总结
Isolated vertebral artery occlusions (VAO) account for approximately one third of posterior circulation occlusions, but have been given the least attention among posterior circulation strokes. If the two recent ATTENTION and BAOCHE randomized clinical trials have proven the superiority of endovascular thrombectomy (EVT) in basilar artery occlusions, data on the effectiveness and harm of acute revascularization treatment on isolated VAO is scarce. We aim to investigate the impact of acute recanalisation treatments in acute ischemic stroke patients with isolated VAO.
In the absence of RCT, observational data with appropriate statistical methods may give indications on benefits and harms of treating neglected stroke situations like acute vertebral occlusion. Results may also lay the basis for prospective studies, such as randomized clinical trials.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
3-month modified Rankin scale
时间窗: 90 days
3-month functional outcome, \[range: 0-6, 0= no symptoms, 6=death\]
次要结局
- EVT procedural complications(During EVT procedure or peri-procedural)
- Cerebrovascular ischemic recurrences(90 days)
- Symptomatic intracerebral haemorrhage (sICH)(7 days)
- 24-hour NIHSS(24 hours)
- Vessel recanalisation on follow up-imaging(48 hours)
- Early neurological deterioration (ENDi)(24 hours)
- 24h and 3month mortality(24h and 90 days)
研究者
Dr. med. Alexander Salerno, MD
Clinical Researcher, Principal Investigator
Centre Hospitalier Universitaire Vaudois