Preemptive Acetaminophen for Postoperative Pain Control Following Minimally Invasive Hysterectomy: a Randomized Control Trial
试验速览
- 阶段
- 2 期
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- Post-operative opioid use
研究概览
简要总结
This study is investigating whether administration of acetaminophen the day before surgery improves post operative pain following minimally invasive hysterectomy. Patients will receive either acetaminophen or placebo to take twice per day the day prior to their scheduled surgery. The morning of surgery all participants will receive oral acetaminophen at least 30 minutes prior to surgery. The investigators will examine whether there is a difference in post operative pain between the two groups.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Undergoing minimally invasive hysterectomy for benign indications
排除标准
- •acetaminophen allergy
- •liver disease
- •kidney disease
- •consume >3 alcoholic beverages per day
- •weigh <50 kilograms
- •report daily opiate use
- •contraindication to acetaminophen
- •used acetaminophen within 24 hours of surgery
- •undergoing a concomitant pelvic reconstructive procedure
研究组 & 干预措施
Preemptive acetominophen
Acetaminophen 975mg BID the day before surgery and again 30-60 minutes preoperatively
干预措施: Acetaminophen (Drug)
Standard of care
Placebo the day before surgery and acetaminophen 30-60 minutes preoperatively
干预措施: Placebo (Drug)
结局指标
主要结局
Post-operative opioid use
时间窗: 4 hours
The total amount of opiate consumption in the immediate postoperative period will be recorded. Per standard protocol, patient's will be ordered for pain medication to receive on an as needed basis. The amount of both oral and IV opioids consumed by the patient will be converted to total morphine equivalents. As such, post operative opioid use will be used as a proxy for degree of post operative pain.
次要结局
未报告次要终点