Impact of Variable Types of Preconditioning Upon the Inotrope Score in Adult Patients, Undergoing Cardiac Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Highest inotropic score
研究概览
简要总结
Preconditioning (PC) of the heart occurs when brief exposure to a stimulus protects the heart from subsequent ischemia. PC stimulus may be (ischemic ; pharmacologic or Physical).
详细描述
Preconditioning (PC) of the heart occurs when brief exposure to a stimulus protects the heart from subsequent ischemia. PC stimulus may be ( ischemic ; pharmacologic or Physical)
Pharmacological PC may be induced by variable agents e.g. (Sevoflurane ;isoflorane, opioids etc)
Ischemic PC includes local; remote and the idea is temporary interruption of blood supply to the organ so that liberation of protective mediators occurs. The liberated mediators have favorable effects not only upon the myocardium, but it extend to protect other organs against inflammatory activation; ischemia reperfusion injury
Inotropic score (IS) is already an evident predictor of postoperative cardiac morbidity and mortality
Aim of the work:
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Supportive Care
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18-60 years old
- •American Society of Anesthesiologists physical status II and III
- •Patients scheduled for open heart surgery
排除标准
- •Emergency surgery
- •Clinically significant kidney or liver disease
- •Patients allergic to local anesthetic
- •Patients with prolonged cardiopulmonary bypass time (>120 min)
- •Patients required intra-aortic balloon pump
- •Postoperative hemodynamic instability (including the occurrence of serious arrhythmia) or bleeding that required surgical re-exploration
研究组 & 干预措施
A pharmacologic cardiac preconditioning
Sevoflurane as a pharmacologic preconditioner for the heart
干预措施: A pharmacologic cardiac preconditioning (Sevoflurane) (Drug)
B ischeamic preconditioning
ischemic preconditioning by inflation the cuff of blood pressure
干预措施: B ischeamic preconditioning (Procedure)
结局指标
主要结局
Highest inotropic score
时间窗: first 24 hour
次要结局
未报告次要终点
研究者
Emad Zarief , MD
Lecturer of Anesthesia and critical care Medicine
Assiut University