NL-OMON30544尚未招募不适用
Acetylcysteine for Treatment of Sickle Cell Disease - N-acetylcystein for Sickle Cell Disease
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 10
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •1. High performance liquid chromatography confirmed diagnosis of HbSS, HbSC or HbSb genotype
- •2. Aged 18-65 years
- •3. Written informed consent
排除标准
- •1. Bloodtransfusion in the preceding four months
- •2. Pregnancy or the desire to get pregnant in the following 7 months
- •3. Concommitant use of hydroxyurea, oral anticontraceptives or other estrogen containing preparations, vitamin K antagonists or other oral anticoagulants, or contraindications for NAC.
- •4. Impaired renal function of more than 60% (as assessed by the Kockroft-Gauld equation)
- •5. Known gatsric or duodenal ulcer
- •6. Concomittant use of anti-hypertensives, sildefanil or nitrates.
研究者
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Acetylcysteine in patients with Sickle Cell Disease: Reducing the incidence of daily life pain in patients with sickle cell diseaseEUCTR2012-004892-37-BEAcademic Medical Center140