The Effect of Perioperative Lidocaine Intravenous Infusion on Neutrophil Extracellular Trapping After Surgery for Stomach Cancer
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- serum concentration of NET(neutrophil extracellular trapping)-related biomarker
研究概览
简要总结
To investigate the effect of perioperative lidocaine infusion on the neutrophil extracellular trapping after minimally invasive surgery for stomach cancer
详细描述
To investigate the effect of perioperative lidocaine infusion on the neutrophil extracellular trapping, especially citrullinated histone3, neutrophil elastase, myeloperoxidase
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •diagnosis of stomach cancer
- •ASA class I-III
- •no metastatic disease
排除标准
- •hepatic, renal disease
- •chronic inflammatory disease, eg. rheumatoid arthritis
- •steroid or anti-inflammatory drug medication
- •allergies to study drugs
- •neuropsychiatric disease
- •refusal of participation
- •breast feeding or pregnancy
- •weight < 40 kg
研究组 & 干预措施
study group
The study group receives the intravenous 1% lidocaine 1.5 mg/kg bolus followed by 1.5 mg/kg/h during surgery and 1.0 mg/kg/h until 24 hours after surgery (Max.<120 mg/h).
干预措施: Lidocaine (Drug)
control group
The control group receives intravenous normal saline 0.15 ml/kg bolus followed by 0.15 ml/kg/h during surgery and 0.1 mg/kg/h until 24 hours after surgery.
干预措施: normal saline (Drug)
结局指标
主要结局
serum concentration of NET(neutrophil extracellular trapping)-related biomarker
时间窗: 24 hours after surgery
NET-related biomarker (citrullinated histone3, neutrophil elastase, myeloperoxidase)
次要结局
- survival of patients(5 years)
- quality of recovery(24 hours after surgery)
- postoperative pain(24 hours after surgery)
研究者
Young Eun Moon
Associate professor
The Catholic University of Korea