NCT04810702招募中不适用
Impact of Von Willebrand Factor and Its Multimers on Angiogenesis
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- To study the relationship between proteins involved in angiogenesis and the distribution of multimers in patients with von Willebrand disease in order to define markers of interest
研究概览
简要总结
The study aims to study the expression of numerous proteins involved in angiogenesis in 70 patients with von Willebrand disease in order to try to identify markers of interest. Secondly, the investigators plan to investigate whether there is a relationship between the proteins tested, the distribution of multimers and the clinical phenotype of the patients, in particular by looking for the presence of bleeding linked to the presence of angiodysplasias.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •For patients:
- •Patient with von Willebrand disease proven by genetic analysis of the VWF gene.
- •Lack of treatment that could interfere with angiogenesis.
- •Patient informed by an information note sent to his home, with the possibility of objecting to the use of his blood samples in the context of research.
- •For the control:
- •Patient with a normal coagulation report
- •Absence of abnormal hemorrhagic symptoms
- •Lack of notion of angiodysplasia.
- •Lack of treatment that could interfere with angiogenesis.
- •Patient informed by an information note sent to his home, with the possibility of objecting to the use of his blood samples in the context of research.
排除标准
- •Patient under guardianship or curatorship.
- •Pregnant and lactating women.
- •Blood transfusion or treatment with von Willebrand factor concentrates less than 7 days old.
- •Treatment which may interfere with angiogenesis.
结局指标
主要结局
To study the relationship between proteins involved in angiogenesis and the distribution of multimers in patients with von Willebrand disease in order to define markers of interest
时间窗: 1 year
Compare the distribution of protein assays between different groups of patients and the control group
次要结局
- To study the relationship between the distribution of multimers and the clinical phenotype of patients, and in particular the presence of angiodysplasias(1 year)
- To study the relationship between the markers of interest and the clinical phenotype of patients, and in particular the presence of angiodysplasias(1 year)
研究者
研究点 (1)
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