MgSO4 Combined With Rocuronium Priming
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- time from injection of induction dose of rocuronium until 95% depression of TOF
研究概览
简要总结
Priming with either rocuronium or MgSO4 is known to accelerate the effect of rocuronium on muscle relaxation. The purpose of this study is to define the effect of MgSO4 on the rocuronium-priming.
详细描述
Acceleration of muscle relaxation is beneficial in rapid-sequence intubation. If MgSO4 combined with priming is efficient in accelerating muscle relaxation, it would be an interesting alternative to rapid-sequence intubation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients of ASA Ⅰ-Ⅱ
- •aged 18~65
- •scheduled to undergo elective surgery under general anesthesia
排除标准
- •risk of pulmonary aspiration
- •anticipated airway difficulty
- •reactive airway disease
- •allergic to study drugs
- •neuromuscular / cardiovascular/ renal/ hepatic disease
- •atrioventricular conduction disturbance
- •BMI < 18.5 or > 24.9
- •chronic treatment with calcium channel blocker
- •medications which affect muscle relaxation
研究组 & 干预措施
priming
patients in this group receive 0.06mg/kg of rocuronium before 0.54mg/kg of rocuronium.
干预措施: priming (Drug)
Mg&priming
Patients in this group receive MgSO4 50mg/kg and 0.06mg/kg of rocuronium before administration of 0.54mg/kg of rocuronium.
干预措施: magnesium sulfate and priming (Drug)
MgSO4
Patients in this group receive intravenous MgSO4 before administration of rocuronium.
干预措施: magnesium sulfate (Drug)
结局指标
主要结局
time from injection of induction dose of rocuronium until 95% depression of TOF
时间窗: time from injection of induction dose of rocuronium until 95% depression of TOF, upto 5 min
次要结局
- rocuronium duration(time from injection of induction dose of rocuronium until train-of-four count reaches two.)
- intubating condition(time from injection of induction dose of rocuronium until tracheal intubation.)
研究者
Kim Mihyun
full instructor
Seoul National University Bundang Hospital