QT Variability Pre & Post Cardioversion in Patient's With Atrial Fibrillation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 219
- 试验地点
- 1
- 主要终点
- QT variability before and after direct current cardioversion
研究概览
简要总结
The purpose of this study is to learn whether the chemicals in the blood and urine are different when the heart is atrial fibrillation compared to normal sinus rhythm.
详细描述
Atrial Fibrillation variably activates the renin-angiotensin-aldosterone system (RAAS), stimulates the sympathetic nervous system, generates oxidant stress, produces natriuretic peptides, and increases ventricular rate. These are interrelated responses and the extent to which these or other pathophysiologic responses determine QT interval during and after Atrial Fibrillation (AF) is unknown. In this study, the QT variability is related to those potential markers in patients with AF undergoing elective DC-cardioversion.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 21 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •At least 21 years of age
- •Scheduled to undergo an elective DC-Cardioversion of atrial fibrillation or atrial flutter at Vanderbilt University Medical Center
排除标准
- •Undergoing emergent DC-Cardioversion of atrial fibrillation for hemodynamic instability
- •Undergoing DC-Cardioversion for post-cardiac surgery
- •Dual chamber pacemakers
结局指标
主要结局
QT variability before and after direct current cardioversion
时间窗: 1.5
次要结局
未报告次要终点
研究者
Dawood Darbar
Associate Professor of Medicine and Pharmacology
Vanderbilt University