Risk Factors for Acute Kidney Injury in Critically Ill Patients With Acute-on-Chronic Liver Failure
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- AKI
研究概览
简要总结
Acute kidney injury (AKI) is one of the most important factors associated with increased mortality in patients with acute-on-chronic liver failure (AoCLF). Early identification and treatment of this subgroup of patients may improve survival and decrease ICU length of stay. As kidney ischemia is one of the main mechanisms responsible for AKI in AoCLF, an increase in urinary to arterial partial pressure of oxygen may help in the early diagnosis of renal failure. For this arterial and urinary oxygen pressure will be measured at ICU admission, on day 1 and day 3 of ICU stay. Diagnosis of AKI within the first 28 days after ICU admission will be recorded
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients admitted to the ICU for acute-on-chronic liver failure
排除标准
- •pre-existing renal disease
- •urine output<200 mL/day
- •death within the first 24 hours after ICU admission
- •emergency liver transplantation within the follow-up period (28 days)
结局指标
主要结局
AKI
时间窗: 28 days after ICU admission
incidence (%) of AKI in patients with AoCLF as defined by Acute Kidney Injury Network guidelines
次要结局
- arterial to urinary oxygen gradient(ICU admission, ICU day 1 and ICU dy 3)
- mortality(28-days)
研究者
Popescu Mihai
clinical professor
Institutul Clinic Fundeni