Functional MRI biomarkers of cognitive decrements in diabetes - Functional MRI in DM2

Medisch Universitair Ziekenhuis Maastricht0 个研究点目标入组 132 人开始时间: 待定最近更新: 2024年5月6日

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•subjects aged 40-75 years, subjects enrolled in the existing 'Maastricht Study', Subjects gave written consent to be approached for additional research, subjects belong to the 20% of the worst and 20% of the best performing (as based on neuropsychological cognitive testing) individuals.;Diabetes type 2:
•fasting blood glucose >= 7.0 mmol/l, after an oral glucose tolerance test (OGTT) blood glucose >= 11.1 mmol/l or used oral glucose-lowering medication or insulin.;Metabolic Syndrome:
•Participants should meet three out of 5 of the following criteria:
•1. Waist circumference > 88 cm (women), > 102 cm (men)
•2. Triglycerides >= 1.7 mmol/l
•3. HDL cholesterol < 1.3 mmol/l (women), < 1.0 mmol/l (men)
•4. Blood pressure >= 130/85 mmHg (or medication)
•5. Fasting blood glucose >= 6.1 mmol/l, after an OGTT blood glucose >= 7.8 mmol/l;Healthy controls:
•Who fulfilled no more that 1 criterium of the metabolic syndrome, no Diabetes type 2.

•Contra-indications for MRI examination:
•1) pacemaker, 2) neurostimulator, 3) medication pump, 4) cochlear or hearing implant, 5) tattoos or other items that cannot be removed and include metal parts, 6) metal splinter in the eye, 7) pregnancy, 8) claustrophobia, 9) brain vessel clamps, 10) denture, which contains magnets, 11) operations in the past, where metal or synthetic material is used and still were in the body ;Psychiatric comorbidity and inability to perform the functional MRI tests.
•Diabetes mellitus type 1 (DM1)
•Subjects who are not belonging to the 20% of the worst and 20% of the best performing individuals
•Last visit of the subjects to the M-Study should be less than one year

发起方

Medisch Universitair Ziekenhuis Maastricht