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临床试验/NCT03969914
NCT03969914已完成不适用

PEEP-induced Changed in RRI as Physiological Background of Ventilator-induced Kidney Injury

Università degli Studi di Ferrara2 个研究点 分布在 1 个国家目标入组 105 人开始时间: 2019年5月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
105
试验地点
2
主要终点
Occurence of AKI

研究概览

简要总结

The renal Doppler resistive index (RRI) is a noninvasive tool that has been used to assess renal perfusion in the intensive care unit (ICU) setting. Many parameters have been described as influential on the values of renal RI. Mechanical ventilation is associated with significant increases in the risk of acute kidney injury (AKI). Ventilator-induced kidney injury (VIKI) is believed to occur due to changes in hemodynamics that impair renal perfusion. The investigators hypothesized that patients who need mechanical ventilation should have a different response in RRI when different levels of Positive end expiratory pressure (PEEP) are applied. Investigators wish to describe changing in RRI due to changes in PEEP and to verify whether these changes could partially explain the occurrence of VIKI

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Patients admitted to ICU with expected mechanical ventilation >48h

排除标准

  • Ultrasound RRI evaluation non available
  • Patients with arrhythmia
  • Pregnancy

结局指标

主要结局

Occurence of AKI

时间窗: once a day until day 7

AKI will be defined according to Kidney Disease: Improving Global Outcomes (KDIGO) criteria

次要结局

  • Change in RRI at different level of PEEP(One a day until day 5)

研究者

发起方
Università degli Studi di Ferrara
申办方类型
Other
责任方
Principal Investigator
主要研究者

Alberto Fogagnolo

Principal investigator

Università degli Studi di Ferrara

研究点 (2)

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