Effect of Propofol on Remifentanil-induced Postoperative Hyperalgesia in Patients Undergoing Thyroid Surgery
试验速览
- 阶段
- 4 期
- 入组人数
- 84
- 试验地点
- 1
- 主要终点
- Tactile pain thresholds adjacent to the surgical wound assessed by von Frey hair before the induction and at postoperative 24 & 48 hrs
研究概览
简要总结
The investigators hypothesize that propofol infusion during surgery can affect the remifentanil hyperalgesia compared to sevoflurane inhalation.The outcome will be measured by a verbal numerical rating score (VNRS) and mechanical punctuating pain by electronic von frey filament.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing thyroidectomy
- •Age 20-65
- •American Society of Anesthesiologists physical status classification I or II
排除标准
- •History of chronic pain, Regular use of analgesic, antiepileptic or antidepressive drugs
- •History of drug & alcohol abuse
- •Psychiatric disorder
- •Use of opioids within 24hrs
- •Renal disease with decreased glomerular filtrate ratio
- •Neuromuscular disease, Severe cardiac disease
研究组 & 干预措施
sevoflurane
Remifentanil will be infused intraoperatively at 0.2 ㎍/㎏/min. patients who are in this group will be infused propofol intraoperatively.
干预措施: propofol, sevoflurane (Drug)
propofol
Remifentanil will be infused intraoperatively at 0.2 ㎍/㎏/min. patients included this group will be inhaled sevoflurane intraoperatively.
干预措施: propofol, sevoflurane (Drug)
结局指标
主要结局
Tactile pain thresholds adjacent to the surgical wound assessed by von Frey hair before the induction and at postoperative 24 & 48 hrs
时间窗: postoperative 48 hrs
次要结局
未报告次要终点