Postoperative Drip-infusion of Remifentanil for Preventing Remifentanil-induced Hyperalgesia- a Retrospective Observative Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 559
- 试验地点
- 1
- 主要终点
- comparison of the numeric rating scale (NRS) between 2 groups
研究概览
简要总结
The development of remifentanil-induced hyperalgesia (RIH) is an unpleasant experience for surgical patients. An alternative management, gradual withdrawal of remifentanil was effective in prevention of RIH. The investigators designed a simple modality to assess if under withdrawal of remifentanil and further drip-infusion of remifentanil immediately after extubation affected postoperative pain score, the requirement of rescue analgesics, and adverse effects.
详细描述
In clinical practice, the gradual withdrawal of remifentanil during surgery is unsatisfied. Thus, the investigators conducted a simple modality in a single center retrospective cohort study to assess how under baseline gradual withdrawal of remifentanil and further drip infusion of remifentanil immediately after extubation affected postoperative pain score and use of analgesics.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •American Society of Anesthesiologists (ASA) score of I-III patients receiving total intravenous anesthesia
排除标准
- •The use of inhalation agents or propofol combined with inhalation anesthesia
- •Pregnancy
- •Previous substance abuse
- •Known allergies to opioids, propofol or any drugs used in the study
- •History of neuropsychiatric disorder
- •Age < 20 years or > 80 years
研究组 & 干预措施
gradual withdrawal following by drip-infusion of remifentanil
In the end of the surgery, gradual withdrawal of remifentanil was prescribed until the endotracheal tube was extubated. Following by drip-infusion of remifentanil for 30 minutes was administered immediately after tracheal extubation.
干预措施: remifentanil (Drug)
结局指标
主要结局
comparison of the numeric rating scale (NRS) between 2 groups
时间窗: one hour
NRS scores is labeled from zero to ten, with zero being an example of someone with no pain and ten being the worst pain possible.
requirement for rescue analgesics
时间窗: one hour
postoperative requirement for rescue analgesics
次要结局
- type of surgery(three hours)
- surgical site(three hours)
研究者
Yi-hsuan Huang
Principal Investigator
Tri-Service General Hospital