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临床试验/NCT05198440
NCT05198440Unknown不适用

Neuromodulation of Motion Illusions (Vection)

University Hospital, Grenoble0 个研究点目标入组 90 人开始时间: 2022年1月30日最近更新:
适应症

试验速览

阶段
不适用
发起方
入组人数
90
主要终点
Change in the latency of first vection between neuromodulations

研究概览

简要总结

Virtual reality systems or simulators are more and more frequently used in the field of learning but also in motor rehabilitation. One of the key points of the success of these systems is the experience of "presence" which is associated with the capacity of these technologies to develop in the observer, who is static, the sensation of moving in the virtual environment (vection). However, the simulation generates a sensory conflict (an optical flow specifying self-motion and vestibular stimuli specifying body immobility). This conflict influences the temporal characteristics of the vection and consequently modifies the way users act in their virtual environment. Thus, contrary to a real situation, vection does not occur instantaneously with the appearance of a visual movement. Moreover, the visual stimulus often generates alternating periods of perception of movement of the environment and of oneself (bistable perception) which can lead to "simulator sickness", a disabling situation for the user. Thus, as vection is an essential element to allow an "optimal transfer of learning" from the simulator to reality, it may be important to promote its emergence while limiting its bistability.

The aim of this project is to study the inhibitory or facilitative modulation of the emergence of the vection phenomenon by the use of non-invasive cortical stimulation techniques (transcranial electrical stimulation (tES), transcranial alternative current stimulation (tACS), and repeated transcranial magnetic stimulation (rTMS)).

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Basic Science
盲法
None

入排标准

年龄范围
18 Years 至 40 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • Healthy subjects aged 18 to 40 years
  • Right-handed subjects
  • Signed informed consent,
  • Medical examination performed prior to participation in the research,
  • Affiliation to or beneficiary of a social security plan

排除标准

  • Contraindications (CI) to the practice of MRI, EEG, TMS & tES
  • Existence of a severe general condition: cardiac, respiratory, hematological, renal, hepatic, cancerous,
  • Regular use of anxiolytics, sedatives, antidepressants, neuroleptics,
  • Characterized psychiatric pathology,
  • Ingestion of alcohol before the examination,
  • Pregnant, parturient or breastfeeding women
  • Person deprived of liberty by judicial or administrative decision, person under a legal protection measure (under guardianship or curators)
  • Participation in other interventional research protocols in progress with an exclusion period or in the previous week Subject who would receive more than 4500 euros of compensation due to his participation in other research involving the human person in the 12 months preceding this study

结局指标

主要结局

Change in the latency of first vection between neuromodulations

时间窗: During the two experimental sessions, at day 1 and up to day 15

Time required for the appearance of a vection before and after neurostimulation (latency in s).

Change in the vection intensity between neuromodulations

时间窗: During the two experimental sessions, at day 1 and up to day 15

Intensity of vection before and after neurostimulation (subjective scale from 0 to 10).

Change in the vection duration between neuromodulations

时间窗: During the two experimental sessions, at day 1 and up to day 15

Perceived total time experiencing vection during visual stimulation before and after neurostimulation (s).

Change in the vection frequency between neuromodulations

时间窗: During the two experimental sessions, at day 1 and up to day 15

Frequency of vection episodes during a period of visual stimulation before and after neurostimulation (%).

次要结局

  • Change in brain activity (as measured by EEG - EP) between neuromodulations(During the two experimental sessions, at day 1 and up to day 15)
  • Change in brain activity (as measured by EEG - spectrum) between neuromodulations(During the two experimental sessions, at day 1 and up to day 15)
  • Change in brain activity (as measured by EEG - connectivity) between neuromodulations(During the two experimental sessions, at day 1 and up to day 15)

研究者

发起方
University Hospital, Grenoble
申办方类型
Other
责任方
Principal Investigator
主要研究者

Thierry Bougerol, MD

Professor

University Hospital, Grenoble

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