Phase 4 - Ozone Therapy in Endodontic Practice, in Vivo Study
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Acceleration in repair by healing of apical periodontite
研究概览
简要总结
The ozone therapy has been coming up as a new therapeutic modality. Medicine has been practicing since XIX century and counted great results. It is indicated for the treatment of 260 different pathologies. The researches in Dentistry has showed promising results, indicating a wide spread action in whole dental specialties. The great oxidative power of ozone provides a great antimicrobial effect and it increases the adenosine triphosphate (ATP) synthesis that can be considered as a general improvement of the cell metabolism, which can potentize the repair process. Thus, these facts justify the present study which will assess the increase of speed of apical periodontite repair.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 13 Years 至 60 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy patients
- •Radiographic evidence of apical periodontite
- •No previous root canal treatment
排除标准
- •Unhealthy patients
- •Regular response to sensibility test
- •Previous root canal treatment
研究组 & 干预措施
Ozone Gas
Endodontic protocol preconized by University of Sao Paulo associated to ozone gas 40 mg/L
干预措施: Ozone (Drug)
Control
Regular endodontic protocol preconized by University of Sao Paulo
干预措施: Control (no last irrigation) (Drug)
Aqueous Ozone
Endodontic protocol preconized by University of Sao Paulo associated to Aqueous ozone 40mg/L
干预措施: Aqueous Ozone (Drug)
结局指标
主要结局
Acceleration in repair by healing of apical periodontite
时间窗: 3 months
次要结局
未报告次要终点
研究者
Carlos Goes Nogales
Master
University of Sao Paulo