Effects of Breaking up Prolonged Sitting on Postprandial Cardiometabolic Disease Risk Markers in Normal Weight Versus Overweight and Obese South Asian Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 54
- 试验地点
- 2
- 主要终点
- Postprandial glucose
研究概览
简要总结
The purpose of this study is to examine whether breaking up prolonged sitting with short regular bouts of walking can reduce blood sugar and cholesterol levels after eating, which are risk markers for Type 2 diabetes and heart disease. This study will compare these responses in normal-weight versus overweight/obese South Asian adults.
详细描述
Participants will attend a preliminary testing session where height, weight, body fat and waist circumference will be measured. They will be familiarised with a motorised treadmill that will be used during the experimental visit below and will take part in an exercise test to determine a light-intensity walking speed for the experimental visit.
Participants will then attend two experimental visits in a random order:
- Prolonged sitting (SIT): Participants will remain seated for 5 hours and instructed to reduce excessive movement.
- Breaking up sitting with walking breaks (INT-SIT): Participants will rise from the seated position every 30 minutes throughout the experimental period to walk on a motorised treadmill at a light intensity for 5 minutes. After performing walking activity, they will return to the seated position. In addition, blood sample will be taken at the resting position just before each physical activity bout. The activity breaks will be undertaken on 9 occasions, providing a total of 45 min of light-intensity activity.
During each visit, blood pressure will be taken 11 times and blood samples will be taken 10 times. Participants will be given a breakfast and lunch meal to consume.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Self-identified South Asian ethnicity.
- •Self-report sitting at least 7 hours per day.
- •Normal weight, overweight or obese.
排除标准
- •Unable to speak and read English.
- •Contraindications to performing light-intensity walking.
- •Diagnosed cardiovascular disease or diabetes.
研究组 & 干预措施
Prolonged sitting (SIT), then breaking up sitting with walking breaks (INT-SIT)
Firstly, participants will remain seated for 5 h and instructed to reduce excessive movement, only rising from the chair to void. After a washout period of at least 3 days, they then performed the INT-SIT condition.
Prolonged sitting (SIT): See SIT arm description Breaking up sitting with walking breaks (INT-SIT): See INT-SIT arm description
干预措施: Prolonged sitting (SIT) (Other)
Breaking up sitting with walking breaks (INT-SIT), then prolonged sitting (SIT)
Firstly, participants will rise from the seated position every 30 min throughout the experimental period to walk on a motorised treadmill at a light intensity walking (as determined during the preliminary test) for 5 min. Participants will start walk on a treadmill at 30 min (so physical activity would be at 30-35 min), 60 min (physical activity will be at 60-65 min), 90 min (physical activity will be at 90-95 min), 120 min (physical activity will be 120-125 min), 150 min (physical activity will be at 150-155 min ), and 180 min (physical activity will be at 180-185 min) in the breakfast postprandial period and 30 min (physical activity will be 30-35 min), 60 min (physical activity will be at 60-65 min), and 90 min (physical activity will be at 90-95 min) in the lunch postprandial period. After performing a walking activity, they will return to the seated position. After a washout period of at least 3 days, they then performed the SIT condition.
SIT : See SIT arm description
干预措施: Breaking up sitting with walking breaks (INT-SIT) (Other)
结局指标
主要结局
Postprandial glucose
时间窗: Measured over the 5 hour condition period
Net incremental area under the curve for each 5 h condition will be calculated for glucose
Postprandial Glucose
时间窗: Measured over the 5 hour condition period
Incremental area under the curve for each 5 h condition will be calculated for glucose
次要结局
- Postprandial triglycerides(Measured over the 5 hour condition period)
- Postprandial insulin(Measured over the 5 hour condition period)
- Blood pressure(Measured over the 5 hour condition period)
- Postprandial Triglycerides(Measured over the 5 hour condition period)
- Postprandial Insulin(Measured over the 5 hour condition period)
- Metabolic Load Index(Measured over the 5 hour condition period)
- Resting Energy Expenditure(Measured for the 5 hour condition period)
- Resting Fat Oxidation(Measured for the 5 hour condition period)
- Resting Carbohydrate Oxidation(Measured for the 5 hour condition period)
- Mean Arterial Pressure(Measured over the 5 hour condition period)
- Heart Rate(Measured over the 5 hour condition period)
研究者
Dr Daniel Bailey
Reader in Sedentary Behaviour and Health
University of Bedfordshire