Physical Activity is Healthy - Effect of Weight Loss or Physical Training Per se?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Change in insulin sensitivity
研究概览
简要总结
The investigators aimed to evaluate the health benefits of physical training per se, weight loss per se and exercise-induced weight loss in young, overweight men. The investigators hypothesized that physical training would have independent effects on various health parameters (insulin sensitivity, fasting glucose and insulin, total and abdominal fat mass, waist circumference, blood pressure and key muscle proteins), and that a concomitant weight loss from physical activity would increase the effect.
详细描述
At baseline, during the intervention and in the week following the intervention participants underwent a panel of tests:
- Cardio respiratory fitness
- blood pressure
- anthropometric measures
At baseline and after the intervention a hyperinsulinemic, euglycemic clamp were performed to asses insulin sensitivity.
Tissue and blood samples were also collected for further analysis:
- Total-protein analysis of selected proteins
- Fasting plasma glucose, insulin and free fatty acids
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Overweight (body mass index 25-30 kg/m2)
- •Weight stable (±2 kg during the past 6 months)
- •Body fat% >25%,
- •Maximal oxygen uptake <45 mL/min/kg
- •Sedentary and healthy according to interview
- •Fasting glucose <6.1 mmol/L
- •Blood pressure <140/90 mmHg
- •No first degree relatives with type-2-diabetes
排除标准
- •Resistance training
- •Inability to meet intervention criteria
结局指标
主要结局
Change in insulin sensitivity
时间窗: week 0 and 13
Before and after the 12 week interventions a 1-step, 120 min, hyperinsulinaemic, euglycemic clamp was performed. After an initial 2mL bolus of insulin infusate, insulin was infused at 40 microU/min/kg.
次要结局
- Changes in body composition(DEXA: week 0, 2, 6, 10, and 13; MRI: Week 0 and 13)