Human Hippocampal Oscillations During Visuomotor Exploration
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 56
- 试验地点
- 1
- 主要终点
- Hippocampal Theta Power Under High Cognitive Loads
研究概览
简要总结
The objective of this study is to determine how visuomotor exploration relates to hippocampal activity along its long axis. The study will investigate the neurophysiological mechanisms in the hippocampus during (1) visual exploration in surgical patients using high-resolution iEEG, and (2) ambulatory exploration in patients implanted with RNS devices.
详细描述
Aim 1 - Visual Exploration in Surgical Patients Investigators will study 20 surgical patients with high-resolution intracranial EEG (iEEG) to investigate hippocampal activity during visual exploration. Participants will view between 10-15 panoramic environments using Meta Quest AR/VR glasses while their eye movements and head turns are tracked. Eye-tracking, head-turn, and iEEG data will be synchronized with visual stimuli, and intracranial EEG and single-unit data will be analyzed for changes in neuronal firing and brain activity before and after saccades.
Aim 2 - Ambulatory Exploration in RNS Patients and Healthy Controls Investigators will study 12 epilepsy patients with implanted responsive neurostimulator (RNS) devices and 24 healthy controls (HCs) during real-world exploration. Participants will walk through and explore visually distinct rooms while wearing synchronized high-density EEG (hdEEG), eye-tracking glasses, and body position sensors. Data from hippocampal iEEG, hdEEG, eye tracking, and motion sensors will be synchronized offline to examine brain-behavior relationships and the influence of cognitive load on saccade-hippocampal interactions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •All subjects:
- •Adults (18-70 years)
- •Able to provide informed consent
- •Aim 1: Surgical epilepsy patients' inclusion criteria
- •Implanted hippocampal depth electrodes for Stage 1 epilepsy surgery
- •MMSE>=24
- •Aim 2: RNS patients Inclusion criteria
- •Implanted RNS device with at least one hippocampal depth electrode
- •At least 5 months post-implantation to avoid the post-implant effect
- •Have a relatively low number of seizures, defined as <1 generalized tonic-clonic or other seizure with potential to fall or cause injury per month
- •Able to walk and wear research equipment without assistance
- •MMSE>=24
- •Aim 2: Healthy Control Inclusion criteria • Able to walk and wear research equipment without assistance
排除标准
- •RNS patients, Aim 2:
- •Any generalized tonic-clonic seizure within the last week
- •All subjects:
- •Legally blind
- •Smoking tobacco, marijuana, recreational drugs or alcohol use within 1 week of cognitive testing
- •Unable to give informed consent
- •Pregnancy
研究组 & 干预措施
Healthy Control Participants
Aim 2: Participants will walk between 4-6 rooms within an office floor. Each office will contain generic objects (office furniture, computers, lighting) and unique objects (artwork, photographs, books, and personal items). As control conditions, subjects will first be asked to walk around and between two empty rooms under different lighting conditions and speeds. Participants will also be asked to participate in all awake saccade control conditions (without a visual cognitive load).
干预措施: Ambulatory Exploration (Other)
Epilepsy Surgery Patients
Aim 1: Participants will be presented with between 10-15 unique immersive virtual environments (depending on patient tolerance) for patients to explore using VR glasses. Control tasks will be run to account for eye movements during non-navigation. For recording eye movements in darkness during REM sleep, as part of a control task, 4 electrodes will be placed above and below both eyes, a standard technique in polysomnographic studies.
干预措施: Visual Exploration (Other)
Patients with RNS Devices
Aim 2: Participants will walk between 4-6 rooms within an office floor. Each office will contain generic objects (office furniture, computers, lighting) and unique objects (artwork, photographs, books, and personal items). As control conditions, subjects will first be asked to walk around and between two empty rooms under different lighting conditions and speeds. Participants will also be asked to participate in all awake saccade control conditions (without a visual cognitive load).
干预措施: Ambulatory Exploration (Other)
结局指标
主要结局
Hippocampal Theta Power Under High Cognitive Loads
时间窗: Study Visit (Day 1)
Aims 1 and 2. High cognitive loads defined as visual exploration of a complex scene with goal-driven task.
Hippocampal Theta Power Under Medium Cognitive Loads
时间窗: Study Visit (Day 1)
Aims 1 and 2. Medium cognitive loads defined as visual exploration of a simpler scene with fewer objects.
Hippocampal Theta Power Under Low Cognitive Loads
时间窗: Study Visit (Day 1)
Aims 1 and 2. Low cognitive loads defined as visual exploration of moving dots.
Hippocampal Theta Power Under No Cognitive Loads
时间窗: Study Visit (Day 1)
Aims 1 and 2. Low cognitive loads defined as staring at a blank field of view or REM sleep.
Coherence Time-Locked to the Saccade Under High Cognitive Loads
时间窗: Study Visit (Day 1)
Aims 1 and 2. High cognitive loads defined as visual exploration of a complex scene with goal-driven task.
Coherence Time-Locked to the Saccade Under Medium Cognitive Loads
时间窗: Study Visit (Day 1)
Aims 1 and 2. Medium cognitive loads defined as visual exploration of a simpler scene with fewer objects.
Coherence Time-Locked to the Saccade Under Low Cognitive Loads
时间窗: Study Visit (Day 1)
Aims 1 and 2. Low cognitive loads defined as staring at a blank field of view or REM sleep.
Coherence Time-Locked to the Saccade Under No Cognitive Loads
时间窗: Study Visit (Day 1)
Aims 1 and 2. Low cognitive loads defined as staring at a blank field of view or REM sleep.
次要结局
未报告次要终点