International survey for extubation evaluation and respiratory dynamics in acute respiratory distress syndrome
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 1,000
- 试验地点
- 23
- 主要终点
- To investigate clinical factor available during spontaneous breathing trial and in the early times after extubation for predicting extubation failure in patients who require ventilator support for acute respiratory distress syndrome (ARDS).
研究概览
简要总结
Acute respiratory distress syndrome (ARDS) is a life-threatening condition characterized by widespread inflammatory lung injury and most of the time it requires invasive mechanical ventilation. Recent studies reported that the mortality of mechanically ventilated patients with ARDS is still as high as approximately 40%, which implies that better management strategies for them are needed to improve the outcomes. In the management for the mechanical ventilated patients with ARDS, the timing and judgement for extubation is clinically important, because extubation failure can be associated with worse outcome. Considering that the best method to extubate successfully has not been determined, the clinical management at the timing of extubation can be varied by each institution or each country, and we thought that international survey focusing on the management for extubation of ARDS patients would be needed. This international observational study aims to collect the clinical data of mechanically ventilated ARDS patients related with ventilator weaning and extubation internationally as well as the outcome of ARDS patients with extubation failure. This study also aims to identify predictive factors strongly associated with extubation failure in patients who require ventilator support for the ARDS condition.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 90.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Adult mechanically ventilated patients expected to receive invasive mechanical ventilator for more than 48 hours 2.Patients who meet the diagnosis of ARDS at the start of invasive mechanical ventilation based on a new global definition of ARDS.
排除标准
- •1.Patients who already had tracheostomy at the start of invasive mechanical ventilation 2.Patients who were transferred to participating hospital more than 2 days after the start of invasive mechanical ventilation 3.Patients with terminal conditions at the start of invasive mechanical ventilation 4.Patients who have expressed their refusal to have their clinical data used in research.
结局指标
主要结局
To investigate clinical factor available during spontaneous breathing trial and in the early times after extubation for predicting extubation failure in patients who require ventilator support for acute respiratory distress syndrome (ARDS).
时间窗: From initiating spontaneous breathing trial to 24 hours after extubation
次要结局
- To investigate worldwide epidemiology, management, timing, and outcome for ventilator weaning and extubation in patients who require ventilator support for acute respiratory distress syndrome (ARDS).