Mechanisms of excess risk in aortic stenosis after aortic valve replacement: a prospective single-centre observational cohort study

niversity College London0 个研究点目标入组 192 人开始时间: 2021年3月15日最近更新: 2021年3月30日

适应症

试验速览

暂无简介。

•1. Able to provide written informed consent
•2. Patients with symptomatic, severe AS referred for surgical or transcatheter AVR with one out of the following echocardiographic criteria for severe AS:
•2.1. Effective orifice area [EOA] <1.0 cm²
•2.2. Indexed EOA of 0.6 cm²/m²
•2.3. Peak velocity >4.0 m/s or mean gradient >40 mmHg

•1. More than moderate valve disease other than AS
•2. Patients that have a conventional contraindication for CMR (non-MR conditional pacemakers/implantable defibrillators, claustrophobia)
•3. Renal impairment (creatinine clearance <30 ml/min/1.73m²)
•4. Needle phobic patients that would preclude blood taking
•5. Diagnosis of dilated or hypertrophic cardiomyopathy
•6. Pregnancy/breastfeeding, eGFR <30 ml/min
•7. Inability to complete the protocol, other conditions that would prevent participation in the study.
•8. Adenosine stress perfusion will not be performed in those patients with:
•8.1. Asthma/COPD of sufficient severity to make adenosine contraindicated
•8.2. High-grade conduction disease precluding the use of adenosine
•8.3. Patients with known previous allergic reactions to adenosine
•8.4. LVEF <40%

发起方

niversity College London