A Real World Study of Respiratory Critical Disease.
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 500
- 试验地点
- 1
- 主要终点
- Mortality
研究概览
简要总结
Acute Respiratory Distress Syndrome (ARDS) is a form of acute diffuse lung injury caused by various etiologies, which rapidly progresses to acute respiratory failure. It is characterized by a sudden onset and severe clinical course. Globally, ARDS affects approximately 3 million individuals each year, accounting for about 10% of admissions to intensive care units (ICUs). Due to the lack of specific pharmacological therapies, mechanical ventilation remains the mainstay of treatment. Therefore, identifying and analyzing prognostic factors for ARDS patients is of great significance for improving patient outcomes and reducing the incidence of poor prognosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with underlying diseases associated with high risk of ARDS, including but not limited to: sepsis, pneumonia, multiple trauma, pulmonary contusion, inhalation injury, massive blood transfusion, other high-risk conditions, or other factors causing excessive respiratory drive.
- •Patients meeting the inclusion criteria for a high-risk ARDS population.
- •Patients (or legal representatives) who have provided a signed and dated informed consent form.
排除标准
- •Age under 18 years.
- •HIV infection.
- •Known immunodeficiency disorders (e.g., leukemia, common variable immunodeficiency, etc.).
- •History of solid organ or bone marrow transplantation.
- •Receiving treatment with G-CSF or GM-CSF.
- •Patients with a decision to withdraw from active treatment.
结局指标
主要结局
Mortality
时间窗: Day 60 after ARDS diagnosis
Clinical observation
次要结局
- Chest CT Scan(Monitored daily)
- Complete Blood Count(Monitored daily)
- Serial Arterial Blood Gas Monitoring(Monitored daily after enrollment)
- Fluid Input and Output Balance(Whenever fluid input or output occurs)
- Mechanical Ventilation Monitoring(Every second after intubation)
研究者
Ming Zhong
PI
Shanghai Zhongshan Hospital