CTRI/2018/04/013067招募中Unknown
Comparison of the efficacy of intracuff saline, 1% alkalinized lignocaine and 2% alkalinized lignocaine on endotracheal tube induced haemodynamic changes and emergence phenomena in neurosurgical patients.
Vardhman Mahavir Medical College and Safdarjung Hospital1 个研究点 分布在 1 个国家目标入组 90 人开始时间: 2018年6月2日最近更新:
试验速览
- 阶段
- Unknown
- 状态
- 招募中
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- To compare the incidence of post extubation cough (PEC) and postoperative sore throat (POST)
研究概览
简要总结
-
To compare the efficacy of 2% alkalinized lignocaine with 1% alkalinized lignocaine and saline in reducing postoperative cough and sorethroat.
-
To compare the efficacy of 2% alkalinized lignocaine with 1% alkalinized lignocaine and saline in reducing haemodynamic changes at extubation.
Hypothesis : Intracuff 2% alkalinized lignocaine reduces the incidence of endotracheal tube induced emergence phenomena and haemodynamic changes as compared to 1% alkalinized lignocaine and saline.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Neurosurgical cases of age 18-65 years, either gender with American Society of Anaesthesiologist’s Grade I and Grade II and Glasgow coma scale (GCS)-15/
- •2.Duration of surgery >1 hr.
排除标准
- •1.Patients with history of sorethroat/URTI/ laryngeal or tracheal pathology; asthma /COPD; Stridor / Dysphonia; Oropharyngeal and or neck malformations.
- •2.Patients with predicted difficult intubation />2 attempts of intubation.
- •3.Patients receiving intravenous lignocaine / allergic to Local Anaesthetics.
- •4.Patients who are not immediately extubated after surgery.
- •5.Usage of nasogastric / orogastric tube inrtaoperatively.
结局指标
主要结局
To compare the incidence of post extubation cough (PEC) and postoperative sore throat (POST)
时间窗: 1 hour, 8 hours and 24 hours postoperative period
次要结局
- 1)Haemodynamic changes(2)Postoperative)
研究者
研究点 (1)
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