Sedentary Behavior and Depressive Symptoms: Influence of Specific Domains of Sedentary Behavior
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 84
- 试验地点
- 4
- 主要终点
- Depressive Symptoms
研究概览
简要总结
Depressive symptoms are commonly observed in the general population. Individuals with subclinical forms of depression (e.g., not meet the criteria to major depression disorder) are at increased risk of mortality than the general population which is partially explained by the higher incidence of cardiovascular diseases. Currently, the effectiveness of the frontline treatment for depression is not consensual. Further, it also may be expensive for individuals with mild to moderate depression. Sedentary behavior is an independent risk factor for cardiometabolic diseases and mental disorders. However, recent evidence suggests that not all types of sedentary behavior are equally detrimental. For instance, mentally passive sedentary behavior (e.g., watching TV) appear to be detrimental for health outcomes whereas mentally active sedentary behavior (e.g., desk-based office work) appear to offer health benefits. However, more studies are required to determine the magnitude of association between distinct types of sedentary behaviors (e.g., watching TV, listening to music, talking while sitting, sitting around and doing nothing special) with depressive symptoms as well as randomized clinical trials investigating potential benefits of interventions to replace mentally-passive sedentary behaviors with mentally active sedentary behaviors, light physical activity or moderate-to-vigorous activity in individuals with mild to moderate depression. Therefore, the aim of this proposal is to investigate the influence of mentally passive sedentary behavior (i.e., watching TV, listening to music, talking while sitting, sitting around, and doing nothing special) on depressive symptoms. This is a randomized clinical trial. Participants with mild to severe depressive symptoms will be randomly assigned (1:1) into either INTERVENTION or CONTROL group, using a computer-generated randomization code. Depressive symptoms, quality of life, physical activity, sedentary behavior, body composition, and functionality will be assessed at baseline (PRE) and 4 (POST) months after the experimental period. The INTERVENTION group will participate in a 4-month goal-setting intervention aimed to replace mentally passive sedentary behaviors with mentally active sedentary behaviors, light physical activity, or moderate-to-vigorous activity while CONTROL group will receive general instructions related to WHO guidelines for physical activity.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •individuals aged over 17 years;
- •mild to severe depressive symptoms.
排除标准
- •cancer in the past 5 years;
- •inability to perform the physical tests;
- •prior diagnosis of muscle degenerative disease (e.g., myopathies, amyotrophic lateral sclerosis);
结局指标
主要结局
Depressive Symptoms
时间窗: Baseline (Pre-intervention) and 16 weeks (Post-intervention)
The depressive symptoms will be assessed by Beck's Depressive Inventory (BDI). Score ranges from 0 to 63 points, being higher scores indicative of higher symptoms of depression.
次要结局
- Anxiety Symptoms (primary outcome)(Baseline (Pre-intervention) and 16 weeks (Post-intervention))
- Indirect physical activity levels assessment(Baseline (Pre-intervention) and 16 weeks (Post-intervention))
- Objective physical activity levels assessment(Baseline (Pre-intervention) and 16 weeks (Post-intervention))
- Indirect sedentary behavior assessment(Baseline (Pre-intervention) and 16 weeks (Post-intervention))
- Objective sedentary behavior assessment(Baseline (Pre-intervention) and 16 weeks (Post-intervention))
- Quality of life assessement(Baseline (Pre-intervention) and 16 weeks (Post-intervention))
- Body Weight(Baseline (Pre-intervention) and 16 weeks (Post-intervention))
- Fat mass (kg)(Baseline (Pre-intervention) and 16 weeks (Post-intervention))
- Fat-free mass (kg)(Baseline (Pre-intervention) and 16 weeks (Post-intervention))
- Muscle Function (30-s Sit-to-stand Test)(Baseline (Pre-intervention) and 16 weeks (Post-intervention))
- Muscle Function (Timed-up-and-go)(Baseline (Pre-intervention) and 16 weeks (Post-intervention))
研究者
Hamilton Augusto Roschel da Silva
PhD.
University of Sao Paulo General Hospital