Effect of Genetic Polymorphism on the Occurrence of Post-Operative Atrial Fibrillation After Coronory Artery Bypass Grafting (CABG) Surgery in Egyptian Patients Receiving Beta Blockers
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 256
- 试验地点
- 1
- 主要终点
- Occurrence of Atrial fibrillation
研究概览
简要总结
Postoperative Atrial Fibrillation (POAF) is one of the most common complications following coronary artery bypass grafting (CABG) occurring to 20% - 40% of patients. It is associated with prolonged hospitalization, increased hospital costs, increased complications and mortality rate.
Despite the use of Beta Blockers, approximately 20% of patients develop atrial fibrillation following CABG surgery, suggesting a role for polymorphism in the genes The aim of the present study is to determine the minor allele frequency of some of the genes that affect the beta blockers' response and to determine the association between polymorphism in these genes and the occurrence of postoperative atrial fibrillation after coronary artery bypass grafting in Egyptian patients receiving perioperative beta blockers.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age above 18 years.
- •Candidates for CABG surgery without a concurrent valve surgery.
- •Patients receiving perioperative beta blockers before new onset of postoperative AF.
排除标准
- •Patients who have either persistent or permanent AF, atrial flutter or atrial tachycardia on ECG obtained on the day of the operation.
- •Serum creatinine >2 mg/dL before the surgery.
- •Uncontrolled thyroid disease.
- •Recent treatment with amiodarone before the occurrence of POAF
研究组 & 干预措施
POAF group
Patients who will experience AF at any time during the first six days after the operation.
干预措施: Beta blocker (Drug)
Non POAF group
Patients with a sinus rhythm during the first six days after the operation.
干预措施: Beta blocker (Drug)
结局指标
主要结局
Occurrence of Atrial fibrillation
时间窗: within 6 days after the operation
Atrial fibrillation based on postoperative electrocardiogram. AF diagnostic criteria will include absence of discrete P waves, the RR intervals follow unrepetitive form and the ranges of ventricular rate usually between 90 and 170 beats/min.
次要结局
未报告次要终点
研究者
Dina Mohamed Kamal El gindy
Assistant Lecturer of Clinical Pharmacy
Misr International University