Effects of a Chatbot-Based Intervention on Resting-State Functional Connectivity and Spontaneous Neural Activity in Individuals With Anhedonia
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Intervention-Related Changes in Resting-State Functional Connectivity After the Intervention
研究概览
简要总结
The main aim of the present study is to investigate the effects of a Motivational Interviewing-based artificial intelligence chatbot on resting-state brain function in college students with elevated anhedonia and depressive symptoms. The study will use a randomized active-control intervention design with pre- and post-intervention resting-state functional magnetic resonance imaging assessments.
详细描述
Anhedonia represents a core characteristic of depression and is characterized by reduced experience of pleasure. It is closely related to decreased motivation, altered reward processing, and alterations in intrinsic brain network function. Resting-state fMRI provides a way to examine intrinsic brain activity and functional connectivity without requiring participants to perform a specific task. This is important because changes associated with anhedonia may not only appear during reward-related tasks, but may also be reflected in spontaneous brain network organization.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18-40 years
- •Right-handed
- •Normal or corrected normal visual acuity
- •Participants must show elevated anhedonia and depressive symptoms at screening, defined as a total score of 22 or higher on the Snaith-Hamilton Pleasure Scale and a score of 14 or higher on the Beck Depression Inventory
排除标准
- •History of major central nervous system disorders, such as epilepsy, traumatic brain injury, stroke, or brain tumors.
- •History of severe mental illness, including schizophrenia spectrum disorders, bipolar disorder, or other psychotic disorders.
- •History of substance or alcohol use disorder or substance or alcohol misuse within the past 12 months that may affect study participation or outcome assessment.
- •Individuals currently at high risk of suicide, severe self-harm, or experiencing an acute psychiatric crisis.
- •Individuals who are currently using psychiatric medications or have undergone psychotherapy within the past 4 weeks that may significantly affect mood, motivation, or reward processing.
- •Severe vision or hearing impairments that cannot be corrected and would interfere with task performance.
- •Contraindications to MRI scanning, including metallic implants, pacemakers, severe claustrophobia, or other conditions incompatible with MRI.
- •Pregnancy or breastfeeding.
研究组 & 干预措施
Motivational Interviewing-based AI chatbot group
Motivational Interviewing-based AI chatbot intervention
干预措施: MI Chatbot Interaction (Behavioral)
Active control chatbot group
Active control nature-story chatbot intervention
干预措施: Active Control Chatbot Interaction (Behavioral)
结局指标
主要结局
Intervention-Related Changes in Resting-State Functional Connectivity After the Intervention
时间窗: Baseline before the first chatbot interaction and Week 1 after completion of the chatbot intervention.
Resting-state fMRI will be used to examine functional connectivity among predefined regions involved in reward, social, and self-referential processing. Connectivity will be estimated from Pearson correlations between regional BOLD time series and then converted using the Fisher z transformation. Changes from baseline to post-intervention will be reported as dimensionless Fisher z values.
次要结局
- Intervention-Related Changes in Spontaneous Activity After the Intervention(Baseline before the first chatbot interaction and Week 1 after completion of the chatbot intervention.)
研究者
Benjamin Becker
Professor
University of Electronic Science and Technology of China