HDL-Cholesterol is Inversely Related With Inflammation in Cardiac Syndrome X
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 710
- 主要终点
- HDL-Cholesterol
研究概览
简要总结
High density lipoprotein cholesterol (HDL-C) is in the centrum of the process of reverse cholesterol transport from peripheral cells to the liver[10]. HDL-C promotes endothelial generation of nitric oxide (NO) and improves endothelial function and arterial vasoreactivity[11]. In several studies, lower HDL-C level was reported to be associated with increased coronary artery disease (CAD) risk[12-14]. HDL-C also has anti- inflammatory and anti-oxidant activities[15,16]. Concerning anti-inflammatory activity, HDL-C inhibits the activation of monocytes/macrophages and neutrophils[17,18] and inhibits the expression of endothelial adhesion molecules, such as vascular cell adhesion molecule-1 (VCAM-1) and E-selectin[15].
In this study we aimed to investigate the relation of HDL-C level with systemic inflammatory markers in patients with cardiac syndrome X (CSX).
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 47 Years 至 58 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Must be able to get exercise stress test
- •Must be able to have coronary angiography
- •Clinical diagnosis of typical anginaduring rest or effort
- •Abnormal test result for exercise ECG or myocardial perfusion scintigraphy
- •Must have of angiographically normal epicardial coronary arteries
排除标准
- •Patients with valvular heart disease (mitral stenosis and moderate to severe mitral regurgitation
- •Patients with moderate to severe aortic stenosis and regurgitation including mitral annular calcification)
- •Patients with heart failure (left ventricular ejection fraction <50%)
- •Patients with congenital heart disease, cardiomyopathy, left ventricular hypertrophy, right ventricular hypertrophy
- •Patients with cardiac surgery
- •Patients with thyroid disease
- •Patients with anemia
- •Patients with pulmonary diseases
- •Patients with infectious diseases (locally or systemic)
结局指标
主要结局
HDL-Cholesterol
时间窗: 6 MONTHS
HDL-Cholesterol \<40 mg/dL(male) / \< 50mg/dL(female) ==\> low HDL-C
Cardiac Syndrome X
时间窗: 6 months
Patients who have typical anginal chest pain+ischaemic findings at exercise stress test/myocardial scintigraphy + normal epicardial coronaries at coronary angiography ==\> Cardiac syndrome X
Inflammation
时间窗: 6 months
CRP \> 2,98 mg/dL ==\> systemic inflammation
次要结局
未报告次要终点