Evolution of the Lymphocyte Phenotype in Patients With Infection in Intensive Care Unit
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 38
- 试验地点
- 2
- 主要终点
- Lymphocytes numbers variation
研究概览
简要总结
Patients admitted for polytrauma, severe neurological injury, post-operative monitoring or sepsis/septic shock present with significant inflammation, leading to immunoparalysis, which is responsible for infection, particularly prolonged infection. A study of their lymphocyte phenotype over time could help explore the phenomenon of immunoparalysis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Postoperative esophagectomy surveillance within the last 24 hours.
- •Patients with intra-abdominal infection
- •Neurological patients with intubation planned for more than 24 hours (subarachnoid hemorrhage with coma, severe head trauma, ischemic or hemorrhagic stroke with coma).
- •Polytrauma with intubation planned for more than 24 hours
- •Patient aged 18 and over
- •Patient with social security coverage
- •Non-inclusion criteria :
- •Hereditary immune deficiency HIV-AIDS
- •Malignant hemopathies
- •Immunosuppressive treatment other than corticosteroid therapy or chemotherapy
- •Patient under legal protection
- •Pregnant or breast-feeding women
排除标准
- 未提供
研究组 & 干预措施
Phenotyping arm
There is only one arm in the study. All patients (i.e. our 4 target populations) will undergo the same phenotyping procedure.
干预措施: Lymphocyte Phenotyping Procedure (Procedure)
结局指标
主要结局
Lymphocytes numbers variation
时间窗: At the midpoint of the prescribed antibiotic course
\- Numbers of various lymphocytes (LT, LB, NK and their subclasses) at half duration of infection's treatment according to reason for admission (postoperative vs sepsis/septic shock vs polytrauma vs neurological injury)
Lymphocytes percentages variation
时间窗: At the midpoint of the prescribed antibiotic course
\- Percentage rate of various lymphocytes (LT, LB, NK and their subclasses) at half duration of infection's treatment according to reason for admission (postoperative vs sepsis/septic shock vs polytrauma vs neurological injury)
次要结局
- Lymphocytes numbers variation in case of infection(Immediately following resolution of infection)
- Lymphocytes percentages variation in case of infection(Immediately following resolution of infection)