Self-modulation of the Sense of Agency by Means of Real-time Neurofeedback
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 225
- 试验地点
- 2
- 主要终点
- Change in Electrophysiological data, i.e., EEG power in alpha band
研究概览
简要总结
This study investigates whether the sense of agency is sensitive to self-regulation by means of EEG-based neurofeedback. During neurofeedback, the brain activity in response to a motor task is recorded in real-time and displayed back to the participants. The participants can therefore use this information to adapt their performance on the motor task.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Aged > 18 years old
- •Normal or corrected-to-normal visual acuity
- •Willing to participate in the study (by signing the informed consent form)
- •Neither caffein, nor alcohol intake 48 hours prior to the experiment
- •Regular intake of drugs (except oral contraceptives in women)
- •Employed by, or in a dependent relationship with, the sponsor and / or the investigator(s)
- •Sufficient knowledge of German or English to understand study documents and instructions.
- •Inclusion Criteria (patients):
- •A diagnosis of temporal epilepsy (TE), documented via video EEG. OR
- •A diagnosis of psychogenic non-epileptic seizure (PNES), according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), and documented via video EEG.
排除标准
- •Past surgery in the brain
- •History of alcohol or drug abuse
- •Incompatibility with EEG recordings, e.g., inability to stay seated for 90 minutes.
结局指标
主要结局
Change in Electrophysiological data, i.e., EEG power in alpha band
时间窗: Before and immediately after neurofeedback
Brain activity
Change in the subjective perception of the Sense of Agency, i.e., visual analog scale assessing how much control participants feel over the game
时间窗: Before and immediately after neurofeedback
Behavioural performance in response to manipulation of the Sense of Agency (SoA)
Change in Electrophysiological data, i.e., EEG power in theta band
时间窗: Before and immediately after neurofeedback
Brain activity
Change in Electrophysiological data, i.e., EEG power in gamma band
时间窗: Before and immediately after neurofeedback
Brain activity
次要结局
未报告次要终点
研究者
Giuseppe Angelo Zito
Principal Investigator
ETH Zurich