Removal of mtDNA in Plasma by Continous Venovenous Hemofiltration in Sepsis
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Change of mtDNA concentration in plasma
研究概览
简要总结
The plasma level of mtDNA in sepsis is affected by continous venovenous hemofiltation（CVVH）
详细描述
Continous renal replacement therapy （CRRT）has become routine for patients with chronic renal failure ，AKI，fliud overload as well as oliguria in ICU .In clinical patients ，continous venovenous hemofoiltration （CVVH）is actually the method of chioce for CRRT in critically ill and hemodynamic instable patients .CVVH has significant beneficial effects on removing inflammatory cytokines ，improving oxygen index，increasing cardiac index and regulating immune dysfuntion .
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adult septic patients undergoing CRRT
排除标准
- •Missing vists
- •transplatation
- •aquired immunodeficiency syndrome
研究组 & 干预措施
Septic patients require CVVH
continuous venovenous hemofiltration. Continuous renal replacement therapy（CRRT）has become routine for patients with chronic renal failure ，AKI，fliud overload as well as oliguria in ICU .Continuous venovenous hemofiltration（CVVH）is the method of chioce for CRRT in critical ill .CVVH has significant beneficial effects on removing inflammatory cytokines ，improving oxygen index ，decreasing vasopressor requirements，increasing cardiac index and regulating immune dysfunction .
干预措施: continous venovenous hemofiltraion (Procedure)
结局指标
主要结局
Change of mtDNA concentration in plasma
时间窗: befor,6hours, 12hours, after CVVH treatment
The specimens in the prefilter and postfilter blood as well as in the ultrafiltrate were obtained at the beginning of CRRT (T0) and 6 h (T6h), 12 h (T12h) after the setup of CVVH.
次要结局
未报告次要终点
研究者
Xingui Dai
Critical Care Medicine
First People's Hospital of Chenzhou